还原型谷胱甘肽在肾病综合征患者中的应用价值

Application Value Analysis of Reduced Glutathione in Clinical Treatment of Nephrotic Syndrome

目的探究肾病综合征患者在治疗过程中应用还原型谷胱甘肽的效果。方法选取2017年11月至2019年11月本院收治的92例肾病综合征患者作为研究对象,并按照随机数字表法将其分为两组,每组46例。对照组患者采用醋酸泼尼松治疗,试验组患者在醋酸泼尼松治疗的基础上加用还原型谷胱甘肽治疗,比较两组患者的治疗效果、三酰甘油与血清蛋白水平的变化情况。结果试验组患者的治疗总有效率为91.30%,高于对照组患者的73.91%,差异有统计学意义(P<0.05);治疗前,两组患者的三酰甘油与血清蛋白水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的三酰甘油水平明显低于治疗前,血清蛋白水平明显高于治疗前,且试验组三酰甘油与血清蛋白水平的降低或升高幅度大于对照组(P<0.05)。结论在治疗肾病综合征患者的过程中应用还原型谷胱甘肽的效果较好,可使三酰甘油水平有效降低,促使血清蛋白水平明显提高。

Objective To explore the therapeutic effect of reduced glutathione in the treatment of nephrotic syndrome.Methods From November 2017 to November 2019,92 patients with nephrotic syndrome admitted to our hospital were randomly selected as research objects and divided into two groups according to digital table method,46 cases in each group.Patients in the control group were treated with prednisone acetate,while patients in the experimental group were additionally treated with reduced glutathione on the basis of the premise of prednisone acetate treatment.The effect of treatment,changes in triglyceride and serum protein levels of the two groups were compared.Results The total effective rate in the experimental group was 91.30%,which was higher than 73.91%in the control group,the difference was statistically significant(P<0.05).There was no significant difference between the two groups in triglyceride and serum protein levels before treatment(P>0.05).After treatment,the levels of triglyceride and serum protein in the two groups were significantly lower than before treatment,and the levels of triglyceride and serum protein in the experimental group were significantly lower or higher than those in the control group(P<0.05).Conclusion The application of reduced glutathione in the treatment of nephrotic syndrome patients has a good therapeutic effect,which can effectively reduce the level of triacylglycerol and significantly increase the level of serum protein.