生殖系统超声检查在女童真性性早熟诊疗中的价值

Value of reproductive system ultrasonography in the diagnosis and treatment of true precocious puberty in girls

目的探讨生殖系统超声检查在女童真性性早熟诊断及疗效评估中的应用价值。方法选取我院收治的86例性早熟女童,根据促性腺激素释放激素(GnRH)激发试验结果分为真性组(中枢性性早熟)52例和假性组(外周性性早熟)34例,另选同期30例健康女童作为对照组,比较各组子宫及卵巢超声检查结果。真性组采用GnRH类似物治疗,比较治疗前和治疗8个月后子宫及卵巢超声检查结果。结果真性组卵巢长径、横径、前后径及最大卵泡直径均大于假性组和对照组(均P<0.05);假性组与对照组上述各指标比较差异均无统计学意义。真性组子宫长径、横径及前后径均大于假性组和对照组,且假性组上述各指标均大于对照组(均P<0.05)。真性组治疗后卵巢各径线及最大卵泡直径、子宫各径线均较治疗前减小,差异均有统计学意义(均P<0.05)。结论性早熟女童子宫和卵巢均明显增大,真性性早熟女童更为明显;超声在女童性早熟诊断及疗效评估中均有较好价值。

Objective To explore the application value of reproductive system ultrasonography in the diagnosis and efficacy evaluation of true precocious puberty in girls.Methods Eighty-six cases of girls with precocious puberty admitted to our hospital were included in the study.They were divided into 52 cases of the true group(central precocious puberty)and 34 cases of the false group(peripheral precocious puberty)according to the results of the gonadotropin releasing hormone(GnRH)stimulation experiment,and 30 healthy girls in the same period were used as the control group.The results of uterine and ovarian ultrasound examination were compared among the groups.Girls in the true group were treated with GnRH analogue,the results of uterine and ovarian ultrasound examination before and 8 months after treatment were compared.Results The long diameter,transverse diameter,anterior and posterior diameter of the ovary and the largest follicle diameter in the true group were larger than those in the false group and the control group(all P<0.05),there were no statistically significant difference in the above indicators between the false group and the control group.The long diameter,transverse diamete,anterior and posterior diameter of the uterus in the true group were larger than those in the false group and the control group,and the above indicators of the false group were larger than those in the control group(all P<0.05).The diameters of the ovaries,the diameters of the largest follicles,and the diameters of the uterus after treatment in the true group were all smaller than those before treatment,and the differences were statistically significant(all P<0.05).Conclusion The uterus and ovaries of girls with precocious puberty are significantly enlarged,especially in girls with true precocious puberty.Ultrasound has a good value in the diagnosis and evaluation of the efficacy of precocious puberty in girls.