左西孟旦对急性心力衰竭患者心功能、脑钠肽及炎性因子水平的影响

Effects of levosimendan on cardiac function of patients with acute heart failure,brain natriuretic peptide and the level of inflammatory factors

目的研究左西孟旦对急性心力衰竭患者心功能、血清脑钠肽(BNP)及血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平的影响。方法选择广州市第十二人民医院2018年1月至2020年1月收治的100例急性心力衰竭患者为研究对象,按随机数字表法分为对照组(50例)和治疗组(50例)。给予对照组患者盐酸多巴酚丁胺注射液,治疗组患者在此基础上使用左西孟旦注射液,两组患者均持续治疗7 d。比较两组患者治疗后临床疗效,治疗前后心功能及血清BNP、IL-6、TNF-α水平。结果治疗7 d后治疗组患者的临床总有效率为90.00%,高于对照组的68.00%;与治疗前相比,治疗后两组患者左室射血分数(LVEF)水平均升高,且治疗组高于对照组;两组患者左室舒张末容积(LVEDV)、左室收缩末容积(LVESV)及血清BNP、IL-6、TNF-α水平均降低,且治疗组低于对照组(均P<0.05)。结论左西孟旦能有效增强急性心力衰竭患者的心功能,降低血清BNP、IL-6、TNF-α水平,抑制炎症反应发生,且疗效显著。

Objective To study the effects of levosimendan on cardiac function,serum brain natriuretic peptide(BNP),serum interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels in patients with acute heart failure.Methods Selecting 100 patients with acute heart failure admitted to Guangzhou Twelfth People’s Hospital from January 2018 to January 2020 as the research objects,and dividing them into the control group(50 Cases)and the treatment group(50 cases)according to the random number table method.Patients in the control group were given dobutamine hydrochloride injection,and patients in the treatment group were given levosimendan injection on this basis.Patients in both groups were treated for 7 d.The clinical efficacy,cardiac function and serum BNP,IL-6 and TNF-αlevels before and after treatment were compared between the two groups of patients.Results After 7 d of treatment,the total clinical effective rate of patients in the treatment group was 90.00%,which was higher than the 68.00%of the control group;Compared with before treatment,the left ventricular ejection fraction(LVEF)level of the two groups of patients increased after treatment,and the treatment group was higher than the control group;left ventricular end diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV)and serum BNP,IL-6 and TNF-αlevels of the two groups decreased,and the treatment group was lower than the control group(all P<0.05).Conclusion Levosimendan can effectively enhance the heart function of patients with acute heart failure,reduce the serum levels of BNP,IL-6,TNF-α,inhibit the occurrence of inflammation,and have a significant effect.