中医药从脑论治骨质疏松症的机制研究进展

Research progress on the mechanism of osteoporosis treated by TCM based on brain theory

骨质疏松症是我国发病率较高的老年性慢性疾病,发病初期临床症状不明显,随着骨质的流失,会逐渐出现疼痛、驼背、平衡功能下降等严重影响老年人群生活质量的表现。最新指南[1]推荐的一线抗骨质疏松药物如双膦酸盐类、雌激素类等对延缓骨质流失疗效确切,但对于骨质疏松症患者症状的改善短期作用不明显。中医药疗法多靶点的作用契合了骨质疏松症的发病特点,在骨质疏松症的防治过程中有独特的优势。基于对骨质疏松症中医病因、病机的梳理,以及对藏象理论、经络归属的探讨,研究者发现脑高级功能与骨质疏松症关系密切,本文将对此方面的中医药研究成果作初步总结。

Osteoporosis is a chronic disease with high incidence rate in China.The clinical symptoms are not obvious at the beginning of the disease.With the loss of bone,patients will gradually suffer from pain,hunchback,and impaired balance function,which will seriously affect the quality of life of the elderly.The first-line anti osteoporosis drugs recommended by the latest guidelines,such as bisphosphonates and estrogens,have definite curative effect on delaying bone loss,but the short-term effect of improving symptoms of osteoporosis patients is not obvious.The multi-target effect of traditional Chinese medicine therapy accords with the characteristics of osteoporosis,and has unique advantages in the prevention and treatment of osteoporosis.Based on the analysis of TCM etiology and pathogenesis of osteoporosis,as well as the discussion of visceral state theory and meridians attribution,the researchers found that the high-level brain function is closely related to osteoporosis.This paper will make a preliminary summary of TCM research result in this respect.