基于“肝主筋、肾主骨”理论探讨OPG/RANKL/RANK信号轴与绝经后骨质疏松症的筋骨相关性

The relationship between OPG/RANKL/RANK signal axis and postmenopausal osteoporosis was investigated based on the theory of“liver main tendon and kidney main bone”

中医基础理论素有“肝主筋,肾主骨”之说,肝藏血主筋,筋束骨利关节,肾为先天之本,主骨而生髓,肝肾精血同源、筋骨相关,互资互生,二者共同介导机体器官、脏腑的发育、生长与衰退过程,尤其与骨细胞生长代谢机制关系密切。随着中医药分子生物学研究的深入,发现骨保护蛋白(OPG)/核因子-kB受体活化因子(RANK)/核因子-kB受体活化因子配体(RANKL)信号轴在骨代谢中发挥关键作用。本文基于“肝主筋,肾主骨”理论,从绝经后骨质疏松症的病因病机出发,从“肝肾论治,筋骨并重”角度将OPG/RANKL/RANK信号转导系统与骨代谢内环境稳态相结合,为中医药柔肝补肾、调筋养骨机制提供分子生物学、筋骨力学依据支撑,以期进一步指导临床论治。

the basic theory of TCM,known as"the liver advocate muscle,kidney advocate bone",said the liver blood main reinforcement,reinforcement beam of bone and joint,the kidney is the foundation of the nature,the main born bone marrow,liver and kidney JingXie homologous,bones and muscles,mutual information and alternate,the two common mediated the body organs,development,growth and decline of the zang-fu organs,especially closely associated with bone metabolism of cell growth mechanism.With the in-depth study of the molecular biology of traditional Chinese medicine,it has been found that the bone protective protein(OPG)/nuclear factor-kb receptor activating factor(RANK)/nuclear factor-kb receptor activating factor ligand(RANKL)signal axis plays a key role in bone metabolism.In this paper,based on the theory of“liver advocate muscle,kidney advocate bone”,starting from the etiology and pathogenesis of postmenopausal osteoporosis,from the perspective of“kidney differentiation,bones and muscles and”OPG/RANKL/RANK signal transduction system combined with bone metabolic homeostasis,traditional Chinese medicine for liver kidney,reinforced bone mechanism provided molecular biology,bones and muscles mechanics on the basis of support,in order to further guide clinical treatment.