肠道菌群与衰老的研究进展

Research progress between intestinal microbiota and aging

随着人口老龄化的加剧,衰老逐渐成为研究者关注的话题。肠道菌群参与机体正常的生理过程,在维护机体健康方面发挥重要作用。与年轻人相比,老年人肠道菌群的结构和多样性均发生改变,而这些改变将会导致许多疾病。目前为止,肠道菌群与衰老关系的具体机制仍不清楚,需要进一步的探索。许多研究发现肠道菌群与神经退行性疾病、2型糖尿病和衰弱等的发生发展密切相关。本文主要对肠道菌群的结构和功能、肠道菌群与衰老相关疾病以及衰弱的关系进行综述,为促进老年人健康提供新的思路。

With the aggravation of population aging,aging has gradually become a heated topic among researchers.Intestinal microbiota is involved in the normal physiological process in human body and plays an important role in maintaining body health.Compared with young adults,the structure and diversity of intestinal microbiota have changed in the elderly.And these alterations will lead to many diseases.So far,the exact mechanisms of the association between intestinal microbiota and aging are still unclear and should be further explored.Numerous studies have revealed that intestinal microbiota is closely related to the occurrence and progression of neurodegenerative diseases,type 2 diabetes,frailty and so on.This paper has mainly reviewed the structure and function of intestinal microbiota,the relationship between intestinal microbiota and aging-related diseases and frailty,which will provide new ideas to promote the health of the elderly.