脑卒中患者阻塞性睡眠呼吸暂停低通气综合征的相关因素研究

Correlation Study of Causes of Obstructive Sleep Apnea Hypopnea Syndrome in Stroke Patients

目的:分析脑卒中患者阻塞性睡眠呼吸暂停低通气综合征(Obstructive Sleep Apnea-Hypopnea Syndrome,OSAHS)的相关性。方法:选取2019年6月18日至2020年6月18日兖州区人民医院神经内科收治的206例患者作为研究对象,按照不同疾病类型分为观察组(n=126)和对照组(n=80),观察组为非昏迷性脑梗死患者,对照组为非脑卒中患者。收集基线资料,采用多导睡眠监测系统完成睡眠监测工作,分析脑卒中患者OSAHS的相关因素。结果:观察组中92例患者存在OSAHS,其中有78例呼吸紊乱指数(Apnea Hyponea Index,AHI)在20以上。对照组中40例患者存在OSAHS,其中有10例AHI在20以上。经比较,2组受试者年龄、身体质量指数(BMI)、AHI、最低动脉血氧饱和度、最长呼吸暂停时间差异有统计学意义(P<0.05)。观察组内高血压者78例,对照组内高血压者24例,比较后,差异有统计学意义(P<0.05)。多因素回归分析结果表明:最长呼吸暂停时间、最低动脉血氧饱和度、AHI、高血压和脑梗死疾病发生呈显著相关性。结论:OSAHS为脑卒中患者疾病发生的独立高危因素。最长呼吸暂停时间、最低动脉血氧饱和度、AHI、高血压和脑梗死疾病发生呈显著相关性。

Objective:To analyze the correlation of causes of obstructive sleep apnea hypopnea syndrome(OSAHS)in stroke patients.Methods:A total of 206 patients in the department of neurology of Yanzhou District People′s Hospital from June 18,2019 to June 18,2020 were selected as the research objects.According to different disease types,they were divided into observation group(n=126)and control group(n=80).The observation group was non comatose cerebral infarction patients,and the control group was non stroke patients.Baseline data were collected,polysomnography system was used to complete sleep monitoring,and the correlation of causes of OSAHS in stroke patients was analyzed.Results:In the observation group,92 patients had OSAHS,of which 78 patients had apnea hyponea index(AHI)above 20.In the control group,40 patients had OSAHS,10 of them had AHI above 20.By comparison,there were significant differences in age,BMI,AHI,lowest arterial oxygen saturation and longest apnea time between the two groups(P<0.05).There were 78 cases of hypertension in the observation group and 24 cases of hypertension in the control group.After comparison,the difference was statistically significant(P<0.05).Multivariate regression analysis showed that the longest apnea time,the lowest arterial oxygen saturation,AHI,hypertension and cerebral infarction were significantly correlated with stroke.Conclusion:OSAHS is an independent risk factor for stroke.The longest duration of apnea,lowest arterial oxygen saturation,AHI,hypertension and cerebral infarction were significantly correlated with stroke.