树突状细胞与头颈部鳞癌

The dendritic cells in head and neck squamous cell carcinoma

头颈部鳞癌是全球较常见恶性肿瘤之一。尽管采取手术、放疗和化疗相结合的综合治疗方式,其5年生存率仍然仅为55%~65%,且预后生活质量欠佳,临床上迫切需要研发新的治疗方法。随着人们对肿瘤免疫微环境的探索,各种免疫治疗相关的临床研究备受关注,其中包括树突状细胞的应用。树突状细胞作为抗原提呈细胞,在机体免疫与肿瘤的抗争过程中起着重要作用,与之相关的研究也已在多种恶性肿瘤的治疗中取得一定进展。本综述旨在介绍树突状细胞在头颈部鳞癌中的作用及治疗进展。

Head and neck squamous cell carcinoma(HNSCC)is one of the most common malignant tumors in the world.Current treatment involves a combination of surgery,radiotherapy and chemotherapy.However,novel therapy methods are urgently needed to improve its 5-years survival rate and poor prognosis.The exploration of the complex relationships within the tumor immune microenvironment has led to various clinical trials related to immunotherapy which have attracted much attention,including the application of dendritic cells.Dendritic cells are natural antigen-presenting cells that can stimulate anti-tumor immune responses.Encouraging work has been carried out using these cells as vaccines against some tumors.This review aims to introduce the progress in research into dendritic cell related therapy for HNSCC.