摘要
Nicotine is the principal alkaloid of tobacco often manufactured into cigarettes and belongs to a highly addictive class of drugs.Nicotine attenuates the neuroinflammation induced by microglial activation.However,the molecular target(s)underlying anti-inflammatory action of nicotine has not been fully understood.Considering the psychoactive substances morphine,cocaine,and methamphetamine act as xenobiotic-associated molecular patterns and can be specifically sensed by the innate immune receptor Toll-like receptor 4(TLR4),here we sought to delineate whether nicotine and/or its metabolite cotinine may be recognized by the innate immune system via myeloid differentiation protein 2(MD2).
基金
This work was supported by the National Natural Science Foundation of China(91956121,21877106,21807098,and 21850410455)
the Chinese Academy of Sciences(CAS)Pioneer Hundred Talents Program,the Young Talents Program of the Chinese Academy of Agricultural Sciences,and the Natural Science Foundation of Jilin Province(20180101021JC)
Computing time was supported by the Network and Computing Center,Changchun Institute of Applied Chemistry,CAS,the National Supercomputing Center in Guangzhou,and the National Supercomputing Center in Shenzhen.M.R.H.is the recipient of an ARC Future Fellowship(FT180100565)
Director of the Australian Research Council Centre of Excellence for Nanoscale BioPhotonics(CE140100003).
