胰岛自身抗体及生化指标在成人隐匿性自身免疫性糖尿病诊断中的价值分析

Analysis of the Value of Islet Autoantibodies and Biochemical Indexes in the Diagnosis of Latent Autoimmune Diabetes in Adults

目的分析胰岛自身抗体及生化指标在成人隐匿性自身免疫性糖尿病诊断中的价值。方法选择2018年12月—2019年12月该院收治初诊2型糖尿病90例患者,给予胰岛自身抗体及生化指标检查。对成人隐匿性自身免疫性糖尿病组(LADA组,39例)及2型糖尿病组(51例)检验结果进行比较。结果该研究中共检出成人隐匿性自身免疫性糖尿病39例,胰岛素自身抗体(IAA)阳性检出率为25.64%(10/39),抗胰岛素细胞抗体(ICA)阳性检出率为38.46%(15/39),GADA阳性检出率为35.89%(14/39);2型糖尿病组FPG、2 hPG、HbA1c、空腹C肽、餐后2 hC肽分别为(9.09±2.13)mmol/L、(12.18±1.25)mmol/L、(8.64±1.28)%、(1.26±0.29)ng/mL、(3.46±1.83)ng/mL;LADA组FPG、2 hPG、HbA1c、空腹C肽、餐后2 hC肽分别为(13.15±3.07)mmol/L、(13.20±1.17)mmol/L、(9.55±1.57)%、(0.41±0.24)ng/mL、(1.43±0.11)ng/mL,两组差异有统计意义(t=7.403、3.943、3.029、14.824、6.909,P<0.05)。结论临床将胰岛自身抗体与生化指标联合应用于LADA诊断中,可为临床早诊断以及早治疗提供有效依据,临床上值得推广使用。

Objective To analyze the diagnostic value of islet autoantibodies and biochemical indicators in adults with latent autoimmune diabetes.Methods From December 2018 to December 2019,90 patients with newly diagnosed type 2 diabetes were admitted to the hospital,and were tested for islet autoantibody and biochemical indicators.The test results of adult latent autoimmune diabetes group(LADA group,39 cases)and type 2 diabetes group(51 cases)were compared.Results A total of 39 adult latent autoimmune diabetes cases were detected in this study.The positive detection rate of IAA was 25.64%(10/39),the positive detection rate of ICA was 38.46%(15/39),and the positive detection rate of 35.89%(14/39);FPG,2 hPG,HbA1c,fasting C peptide,and postprandial 2 hC peptide in the type 2 diabetes group were(9.09±2.13)mmol/L,(12.18±1.25)mmol/L,(8.64±1.28)%,(1.26±0.29)ng/mL,(3.46±1.83)ng/mL;FPG,2 hPG,HbA1c,fasting C peptide,and postprandial 2 hC peptide in the LADA group were(13.15±3.07)mmol/L,(13.20±1.17)mmol/L,(9.55±1.57)%,(0.41±0.24)ng/mL,(1.43±0.11)ng/mL,the difference between the two groups was statistically significant(t=7.403,3.943,3.029,14.824,6.909,P<0.05).Conclusion The clinical application of pancreatic islet autoantibodies and biochemical indicators in the diagnosis of LADA can provide an effective basis for clinical early diagnosis and early treatment,and it is worthy of clinical application.