磷酸肌酸钠治疗小儿病毒性心肌炎的疗效及对心肌酶和肌钙蛋白水平的影响分析

Efficacy of Creatine Phosphate Sodium in the Treatment of Children with Viral Myocarditis and Its Effect on Myocardial Enzymes and Troponin Levels

目的分析评价磷酸肌酸钠治疗小儿病毒性心肌炎的疗效及对心肌酶和肌钙蛋白水平的影响。方法该次将该院于2018年2月—2019年1月纳入研究的小儿病毒性心肌炎患儿共80例作为研究对象,进一步以随机数表法分为两个不同的组别,每组40例;对照组患儿采取常规对症方法医治,观察组患儿以常规对症医治方法为基础,进一步采取磷酸肌酸钠医治,治疗结束后比较两组临床治疗效果。结果观察组治疗总有效率的95.00%,显著要比对照组的75.00%更高,差异有统计学意义(χ2=6.275,P<0.05)。在心肌酶相关指标水平方面,治疗前两组血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、谷草转氨酶(AST)均差异无统计学意义(P>0.05);在治疗之后,观察组均明显要比对照组更低,差异有统计学意义(P<0.05)。在肌钙蛋白水平方面,治疗前两组肌钙蛋白I(cTnI)、肌钙蛋白T(cTnT)均差异无统计学意义(P>0.05);治疗后,观察组则均明显比对照组更低,差异有统计学意义(P<0.05)。结论磷酸肌酸钠医治小儿病毒性心肌炎的疗效显著,能够使患儿心肌酶和及钙蛋白水平得到有效改善,进一步改善患儿预后效果;因此,值得采纳及应用。

Objective To analyze and evaluate the curative effect of creatine phosphate sodium in the treatment of children with viral myocarditis and its influence on the levels of myocardial enzymes and troponin.Methods A total of 80 children with viral myocarditis in children who were included in the study in the hospital from February 2018 to January 2019 were taken as the research objects.They were further divided into two different groups by random number table method,each group had 40 cases.The control group was treated with conventional symptomatic treatment,and the observation group was treated with conventional symptomatic treatment and further treated with creatine phosphate sodium.After the treatment,the clinical treatment effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 95.00%,which was significantly higher than 75.00%in the control group,the difference was statistically significant(χ2=6.275,P<0.05).In terms of the levels of myocardial enzyme-related indexes,the two groups of serum creatine kinase(CK),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),and aspartate aminotransferase(AST)did not exist before treatment,the difference was not statistically significant(P>0.05);after treatment,the observation group was significantly lower than the control group,the difference was statistically significant(P<0.05).In terms of troponin levels,there was no statistically significant difference in troponin I(cTnI)and troponin T(cTnT)between the two groups before treatment(P>0.05);after treatment,the observation group was significantly better than the control group,the difference was statistically significant(P<0.05).Conclusion Creatine phosphate sodium is effective in treating viral myocarditis in children.It can effectively improve the levels of myocardial enzymes and calcineurin in children and further improve the prognosis of children;therefore,it is worthy of adoption and application.