氧化应激和线粒体质量控制与牙周炎关系的研究进展

Research progress on the relationship among oxidative stress,mitochondrial quality control,and periodontitis

牙周炎主要是由菌斑微生物引起的牙周支持组织的慢性炎症性疾病。近年来,关于线粒体质量控制与牙周炎之间的关系受到学者们的广泛关注。线粒体质量控制包括线粒体的生物发生、动力学和自噬三部分,任何一个部分紊乱都会导致线粒体功能障碍,进而诱发相关疾病。氧化应激会导致线粒体质量控制失衡,可能在牙周炎发展中起关键作用。本文就氧化应激、过氧化物酶体增殖物激活受体-γ共激活因子1α、核呼吸因子1/2、有丝分裂蛋白1/2、动力蛋白相关蛋白1、PTEN诱导的假定激酶1等蛋白引起线粒体功能障碍在牙周炎中的相关研究进展进行综述,旨在为牙周炎的防治提供新的思路。

Periodontitis is a chronic inflammation of the periodontal supporting tissue caused by plaque microorganisms.In recent years,scholars have paid close attention to the relationship between mitochondrial quality control and periodontitis.Mitochondrial quality control includes mitochondrial biogenesis,kinetics,and autophagy.Any part of the disorder will lead to mitochondrial dysfunction and then induce the occurrence of related diseases.Some scholars have pointed out that oxidative stress can lead to an imbalance in mitochondrial quality control,which plays a key role in the development of periodontitis.This article reviews the research progress of mitochondrial dysfunction caused by oxidative stress,peroxisome-proliferator-activated receptor-gamma co-activator 1α,nuclear respiratory factor 1/2,mitofusin 1/2,dynamin related protein 1,PTEN-induced putative kinase 1 and other proteins in periodontitis.It aims to provide new ideas for the prevention and treatment of periodontitis.