引导组织/骨再生牙周功能梯度膜的研究进展

Research progress on periodontal functional gradient membrane for guided tissue/bone regeneration

生物屏障膜(BBM)的应用是引导组织/骨再生(GTR/GBR)技术的关键环节,其主要作用是将牙周缺损区与牙龈组织相隔离,防止牙龈上皮组织向下方的牙周缺损区快速生长,从而为牙周组织的再生创造一个相对封闭的良好环境。理想的BBM应具有足够的机械强度、良好的促成骨及抗炎等诸多性能,然而目前使用的BBM均未能兼顾上述要求,均具有不同程度的缺点,GTR/GBR效果不理想。因此学者们广泛展开了对新一代可吸收GBR/GTR膜的开发和研究。在目前研究较为充分的BBM中,功能梯度膜(FGM)具有提升BBM诸多特性,使之更趋于理想的强大潜力,有增强临床GTR/GBR效果的广阔前景。本文对功能梯度GBR/GTR膜的研究进展进行综述,旨在为其进一步研究和开发提供参考。

The application of biological barrier membrane(BBM)is the key role in guided tissue/bone regeneration(GTR/GBR)technology.Its main function is to isolate the periodontal defect area from gingival tissue,and prevent the gingival epithelial tissue from growing rapidly into the defect area,so as to create a relatively closed and profitable environment for periodontal tissue regeneration.The ideal BBM should have enough mechanical strength,promoting osteogenesis and anti-inflammatory properties.However,the effect of the current commercially GTR/GBR membranes cannot meet the above ideal requirements,and have different degrees of defects.Therefore,scholars have widely carried out the development and research on the new generation of bioabsorbable GBR/GTR membranes.Of the deeply and extensively researched BBM,FGM has great potential to possess the properties of ideal BBM.It has a broad prospect to enhance the clinical effect of GBR/GTR.In this paper,the research progress of functional gradient GBR/GTR membrane is reviewed,in order to provide reference for its further research and development.