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地塞米松不同给药方式治疗分泌性中耳炎的临床对比研究

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摘要 目的探究与分析地塞米松不同给药方式治疗分泌性中耳炎的临床效果。方法选取自2018年4月~2020年4月收治的120例慢性分泌性中耳炎患者,采取随机数字表法分为对照组与观察组,每组各60例,对照组借助内镜,通过鼓膜穿刺的途径给药,观察组借助内镜,通过咽鼓管给药,对比临床疗效、治疗前后水通道蛋白-4及水通道蛋白-1的水平、不良反应发生率。结果观察组的临床总有效率要明显高于对照组,差异有统计学意义(P<0.05)。观察组治疗后与对照组治疗后相比水通道蛋白-4及水通道蛋白-1水平均升高,差异有统计学意义(P<0.05)。两组治疗期间的不良反应发生率无明显差异(P>0.05)。结论借助内镜通过咽鼓管给药治疗慢性分泌性中耳炎的临床疗效显著,可有效调节水通道蛋白的水平,同时治疗期间未增加明显不良反应,安全性较高。
作者 王新龙
出处 《中国处方药》 2021年第6期101-102,共2页 Journal of China Prescription Drug
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