外周血单个核细胞宫腔灌注对反复种植失败患者的影响

Effect of intrauterine perfusion of peripheral blood mononuclear cells on patients with repeated implant failure

目的分析外周血单个核细胞宫腔灌注对反复种植失败患者的影响。方法选取2018年6月~2020年6月行FET的反复种植失败患者80例,随机分为两组,每组各40例,试验组患者于胚胎移植前1 d行外周血单个核细胞宫腔灌注治疗,对照组同期仅行盐水对照。研究两组患者的胚胎着床率、妊娠率、流产率,移植当日子宫内膜厚度等。结果①试验组患者的胚胎着床率、妊娠率显著高于对照组,组间差异比较有统计学差异(P<0.05);试验组患者的流产率与对照组比较差异无统计学意义(P>0.05)。②试验组移植当日子宫内膜厚度为(12.34±1.14)mm显著高于对照组(9.34±1.33)mm(P<0.05)。结论外周血单个核细胞宫腔灌注治疗可显著改善反复种植失败患者的胚胎着床率,提升妊娠率,但是对流产率无明显影响。

Objective To analyze the effect of intrautenine perfusion of peripheral blood mononuclear cells on patients with repeated implantation failure.Methods A total of 80 patients with repeated FET transplantation failures who underwent FET in our department from June 2018 to June 2020 were selected and randomly divided into two groups with 40 cases in each group.Patients in the experimental group received peripheral blood mononuclear cell perfusion treatment one day before embryo transfer,while the control group received only saline control during the same period.The embryo implantation rate,pregnancy rate,miscarriage rate,and endometrium thickness on the day of transplantation were studied in the two groups.Results①The embryo implantation rate and pregnancy rate of the experimental group were significantly higher than those of the control group,and the difference between the groups was statistically different(P<0.05);the abortion rate of the experimental group was not significantly different from that of the control group(P>0.05).②The endometrial thickness of the group on the day of transplantation was(12.34±1.14)mm,which was significantly higher than that of the control group(9.34±1.33)mm(P<0.05).Conclusion Peripheral blood mononuclear cell intrauterine perfusion therapy can significantly improve the embryo implantation rate of patients with repeated transplantation failures,and significantly increase the pregnancy rate,but it has no significant effect on the abortion rate.