新型肠道间质细胞MRISC调控炎症过程中肠道干细胞的损伤修复

Novel Intestinal Mesenchymal Stromal Cell MRISC Regulates Intestinal Stem Cell upon Damage-Induced Tissue Repair and Inflammation

炎症和损伤能迅速激发肠道干细胞增殖促进组织修复再生。肠道微环境组分中的重要成员—肠道间质细胞在这个过程中起到了非常重要的调控作用。近年来,随着单细胞测序技术的快速发展,研究人员揭示了肠道间质细胞是一类异常复杂且具高度异质性的细胞群。目前,领域内对不同肠道间质细胞亚群的基因特征、空间分布、潜在功能以及调节的细胞和分子机制仍知之甚少。该文总结了该团队发现肠道间质细胞新亚群MRISC(MAP3K2-regulated intestinal stromal cell)的过程,并详细描述了MRISC在肠道炎症和损伤过程中通过特异调控肠道干细胞微环境的R-spondin1-Wnt信号参与肠道上皮组织损伤修复的作用和机理,为MAPK信号在肠道疾病研究和治疗中的应用提供了新思路。

Inflammation and tissue damage could rapidly stimulate intestinal stem cell proliferation and promote tissue regeneration.Intestinal mesenchymal stromal cell,one of the key components of intestinal micro-environment,plays an essential regulatory role in this process.With the advancement of single cell sequencing technologies,researchers revealed intestinal mesenchymal stromal cells as a complex and highly heterogeneous cell population.Currently,the gene signature,spatial distribution,potential function,cellular and molecular regulatory mechanisms of these distinctive stromal cell populations are still poorly understood.This paper revisited the course of MRISC (MAP3K2-regulated intestinal stromal cell) discovery,and described the role and mechanism of MRISC involved in intestinal epithelial repair by specifically regulating the R-spondin1-Wnt signal of the intestinal stem cell niche during intestinal inflammation and injury.This work provided new insights in application of MAPK signal perturbation to the research and therapies of intestinal diseases.