不同浓度光敏剂对食管癌疗效的回顾性分析

Retrospective Analysis of the Effect of Different Concentrations of Photosensitizers on Esophageal Cancer

目的研究食管癌光动力治疗时不同剂量浓度光敏剂对疗效的影响。方法收集2019年1月至2020年1月在我院进行光动力治疗的38例中晚期吞咽困难食管癌患者,按照住院期间应用光敏剂量的不同,将其分为高剂量组(3 mg·kg-1)15例和低剂量组(2 mg·kg-1)23例。收集患者术后1个月及3个月的随访资料,分析其缓解率,统计患者术后不良事件的发生率。结果高剂量组Ⅲ~Ⅳ级吞咽不利缓解率为:83.33%(1个月后)、33.33%(3个月后);低剂量组为:78.95%(1个月后)、68.42%(3个月后);术后疼痛:高剂量组86.67%,低剂量组47.83%;穿孔:高剂量组6.67%,低剂量组0.00%;结论光动力治疗食管癌能有效缓解吞咽困难,且低剂量组治疗术后的疼痛、穿孔等不良事件的发生率明显低于高剂量组。

Objective To study the effect of photodynamic therapy with different dose and concentration of photosensitizer on esophageal cancer.Methods A total of 38 patients with advanced esophageal cancer with dysphagia,treated by photodynamic therapy in our hospital from January 2019 to January 2020,were divided into a high-dose group(3 mg.kg-1),15 patients,and a low-dose group(2 mg·kg-1),23 patients.Follow-up data at 1 month and 3 months after surgery were collected to analyze the remission rate.The incidence of postoperative pain and esophageal fistula were calculated.Results The remission rates of gradeⅢ~Ⅳdysphagia in the high-dose group were:83.33%(1 month),and 33.33%(2 months),those of low dose group was 78.95%(after 1 month)and 68.42%(after 2 months).Postoperative pain in high dose group was 88.67%,in low dose group:47.83%.Esophageal fistula incidence in high dose group was 6.67%,in low dose group,0.00%.Conclusion Photodynamic therapy for esophageal cancer can effectively relieve dysphagia,and the incidence of postoperative pain and esophageal fistula in the low-dose group is significantly lower than that in the high-dose group.