CEA、VEGF和IL-6与食管癌患者预后不良的相关性

Correlation of CEA,VEGF and IL-6 with Poor Prognosis in Patients with Esophageal Cancer

目的探讨CEA、VEGF和IL-6与食管癌患者预后不良的相关性。方法以2017年1月至2019年10月在我院治疗的124例食管癌患者为研究对象,按预后情况将患者分为预后不良组和预后良好组,检测患者的CEA、VEGF和IL-6水平,分析CEA、VEGF和IL-6与患者预后的相关性。结果两组食管癌患者的性别、年龄、习性和分期等无统计学差异(P>0.05),预后不良组患者的CEA、VEGF和IL-6水平显著高于预后良好组(P<0.05),差异有统计学意义,且CEA、VEGF和IL-6均与患者预后不良呈正相关(r=0.965,P<0.05;r=0.958,P<0.05;r=0.647,P<0.05),差异有统计学意义。结论CEA、VEGF和IL-6与食管癌患者预后不良有相关性,可以作为临床预后的参考指标。

Objective To investigate the correlation of CEA,VEGF and IL-6 with poor prognosis in patients with esophageal cancer.Methods 124 patients with esophageal cancer who were treated in our hospital from January 2017 to October 2019 were selected and divided into a poor prognosis group and a good prognosis group.The CEA,VEGF and IL-6 levels of these patients were tested,the correlation of these marker with prognosis was analyzed.Results Between the two EC groups,no statistically significant differences were founded for gender,age,life style and staging of esophageal cancer(P>0.05).However,the levels of CEA,VEGF and IL-6 in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05).All these 3 markers were positively correlated with the poor prognosis of esophageal cancer patients(r=0.965,P<0.05;r=0.958,P<0.05;r=0.647,P<0.05,respectively).Conclusion CEA,VEGF and IL-6 are significantly related to the poor prognosis of patients with esophageal cancer,and could be used as indices for prognosis。