食管癌化疗抗性的分子机制

Molecular Mechanism of Chemotherapy Resistance in Esophageal Cancer

顺铂、5-氟尿嘧啶和紫杉醇等在食管癌化疗中的应用十分普遍,但部分食管癌患者对这些药物并不敏感,或者在复发后产生药物抵抗。本文将化疗药物按照进入作用部位的前中后分为靶前、靶上和靶后3大类,分别阐述食管癌患者对上述3种药物产生抗性的分子机制。以期通过对化疗药物抗性分子机制的总结,为临床克服化疗药物的抗性,减少不良反应和延长患者生存时间提供参考。

Cisplatin,5-fluorouracil and paclitaxel are commonly used as chemotherapeutic drugs in esophageal cancer.Unfortunately,some patients with esophageal cancer are not sensitive to chemotherapeutic drugs,or after the tumor relapses,drug resistance frequently occurs.In this article,the resistance mechanism of esophageal cancer to the chemotherapeutic drugs is elaborated by dividing them into three aspects:pre-target,on-target and post-target.Through the understanding of the resistance to chemotherapeutic drugs and the continuous efforts of scientists to overcome the resistance to chemotherapeutic drugs,the side effects to patients can be reduced and the survival time can be prolonged.