摘要
目的探讨胸腺蛋白肽粉对健康人群人体免疫力的影响。方法10名健康志愿者,年龄24~43岁,服用胸腺蛋白肽粉,一日1次,连续60 d,分别于服用前、服用后第14,30,60天采血检测细胞免疫指标。结果CD4^(+)/CD8^(+)比值、CD4^(+)CD45RA^(+)、CD8^(+)CD45RA^(+)、CD3^(+)HLA-DR^(+)、Treg、Tc、Tn、Tm的水平升高(P<0.05),CD3^(+)HLA-DR-的水平降低(P<0.05)结论胸腺蛋白肽粉可促进T细胞分化、发育成熟,从而增强人体细胞免疫功能,提高人体免疫力。
Objective To investigate the effect of thymic protein peptide powder on the immunity of healthy people.Methods Ten healthy volunteers,24-43 years old,took thymic protein peptide powder once a day for 60 consecutive days.Peripheral blood(PB)samples were collected before administration and on the 14th,30th and 60th day after administration for the detection of cellular immune indexes.Results The levels of CD4^(+)/CD8^(+),CD4^(+)CD45RA^(+),CD8^(+)CD45RA^(+),CD3^(+)HLA-DR^(+),Treg,Tc,Tn and Tm increased(P<0.05),and the percentage of CD3^(+)HLA-DR-decreased(P<0.05).Conclusion Thymic protein peptide powder can promote the differentiation and maturation of T cells,improve the function of human immune cells and enhance the immunity of human.
作者
刘铁强
范志恒
吉晓月
宋梦薇
王丽莉
胡亦猛
窦会东
孔双泉
陈西
王玉萍
张宁
LIU Tie-qiang;FAN Zhi-heng;JI Xiao-yue;SONG Meng-wei;WANG Li-li;HU Yi-meng;DOU Hui-dong;KONG Shuang-quan;CHEN Xi;WANG Yu-ping;ZHANG Ning(Department of Hematology,South Hospital of the Fifth Center of Chinese PLA General Hospital,Beijing 100039,China;Beijing Saisheng Pharmaceutical Co.,Ltd.,Beijing 100079,China;Beijing Huatai Yikang Medical Laboratory,Beijing 102629,China)
出处
《食品与药品》
CAS
2021年第3期219-224,共6页
Food and Drug
关键词
胸腺蛋白肽
胸腺肽
T细胞
细胞免疫
thymic protein peptide
thymic peptide
T cell
cellular immunity