肺部穿刺活检联合血清SCC、CEA、NSE诊断肺癌的价值

Value of lung biopsy combined with SCC,CEA and NSE in the diagnosis of lung cancer

目的探讨肺部穿刺活检联合鳞癌抗原(SCC)、癌胚抗原(CEA)、神经元特异度烯醇化酶(NSE)检测诊断肺癌的价值分析.方法选取本院2016年1月至2020年4月就诊的90例确诊肺癌患者为观察组,选取同时期来院就诊的90例肺部良性病变患者及90例健康体检者分别作为良性组与对照组,比较3组血清SCC、CEA、NSE水平,同时分析观察组不同病理类型、分期上述指标的差异,分析肺部穿刺活检、血清SCC、CEA、NSE单独及联合检测在肺癌诊断中的价值.结果观察组血清SCC、CEA、NSE水平均高于良性组及对照组(P<0.05);肺鳞癌者血清SCC水平较肺腺癌及小细胞肺癌明显升高(P<0.05);小细胞肺癌者血清NSE水平较肺腺癌及肺鳞癌明显升高(P<0.05);肺腺癌者血清CEA水平较肺鳞癌及小细胞肺癌明显升高(P<0.05);周围型肺癌穿刺活检阳性率为94.64%,并发症发生率为25.56%;穿刺活检联合SCC、CEA、NSE检测诊断肺癌的敏感度95.56%,特异度100%.结论肺部穿刺活检诊断周围型肺癌阳性率高,并发症少,联合SCC、CEA、NSE检测能提高诊断肺癌的敏感度与特异度,具有较高临床价值.

Objective To study the value of lung biopsy combined with SCC,CEA and NSE in the diagnosis of lung cancer.Methods Ninety patients with lung cancer in our hospital from January 2016 to April 2020 were selected as the observa-tion group,and 90 patients with pulmonary benign disease and 90 healthy persons were selected as benign group and control group respectively.The serum levels of SCC,CEA and NSE in the three groups were compared,and the differences of the above indexes in different pathological types and stages of the observation group were analyzed,and the value of lung biopsy and serum three separate and com bined detection in the diagnosis of lung cancer was analyzed.Results The serum levels of SCC,CEA and NSE in the observation group were higher than those in the benign group or the control group(P<0.05);the serum SCC level of patients with lung squamous cell carcinoma was significantly higher than that of lung adenocarcinoma and small cell lung canc-er(P<0.05);the serum NSE level of small cell lung cancer was significantly higher than that of lung adenocarcinoma and small cell lung cancer(P<0.05);the serum CEA level of lung adenocarcinoma was significantly higher than that of lung squamous cell carcinoma and small cell lung cancer(P<0.05).The positive rate of biopsy was 94.64%and the incidence of complications was 25.56%.The sensitivity and specificity of biopsy combined with SCC,CEA and NSE were 95.56%and 100%,respective-ly.Conclusion Lung biopsy has high positive rate and less complications in the diagnosis of peripheral lung cancer.Combined detection of SCC,CEA and NSE can improve the sensitivity and specificity of diagnosis of lung cancer,and has high clinical val-ue.