氨基酸与糖尿病及认知障碍的相关性研究

Study on the Relationship between Amino Acids,Diabetes and Cognitive Impairment

氨基酸在认知障碍发生的过程中是一类重要的生物标记物,患有糖尿病者比没有糖尿病的患者表现出较差的认知能力和更多的大脑影像异常。目前发现与认知障碍相关的氨基酸有两大类:抑制性氨基酸(inhibitoryaminoacids,IAAs)和兴奋性氨基酸(excitatoryaminoacids,EAAs)。EAAs包括谷氨酸(Glu)和天门冬氨酸(Asp)等,IAAS包括γ-氨基丁酸(GABA)等还有甘氨酸(GLY)。现将围绕这两类氨基酸和糖尿病认知障碍做一综述。

Amino acids is an important biomarker in the process of cognitive impairment.People with diabetes have poorer cognitive ability and more abnormal brain imaging than those without diabetes.At present,there are two major types of amino acids related to cognitive impairment:inhibitory amino acids(IAAs)and excitatory amino acids(EAAs).EAAs include glutamic acid(Glu)and aspartic acid(Asp),while IAAS includes gamma-aminobutyric acid(GABA)and glycine(GLY).This article will focus on these two types of amino acids and diabetic cognitive impairment.