沙美特罗氟替卡松粉吸入剂治疗儿童支气管哮喘疗效及对炎症因子影响分析

Efficacy of Salmeterol Fluticasone Powder Inhalation in the Treatment of Children with Bronchial Asthma and Analysis of its Influence on Inflammatory Factors

目的:观察沙美特罗氟替卡松粉吸入剂治疗儿童支气管哮喘疗效及对炎症因子影响,为临床治疗儿童支气管哮喘提供参考治疗方案。方法:选取2018年1月—2019年1月在郑州大学附属儿童医院治疗的支气管哮喘患儿150例作为研究对象。按照入组顺序编号,采用数字随机表法将其随机分为对照组和观察组,每组75例。其中对照组单用丙酸氟替卡松吸入气雾剂进行治疗,观察组采用沙美特罗氟替卡松粉吸入剂治疗。两组患儿治疗前后均行血清炎症因子水平(CRP、EOS、IL-4、IL-10)检测,治疗后患儿肺部功能指标改变率,判断临床疗效,并对上述指标行组间比较。结果:(1)治疗后两组患儿CRP、EOS、IL-4显著低于治疗前,IL-10显著高于治疗前(P<0.05);观察组患儿治疗后的CRP、EOS、IL-4显著低于对照组,且IL-10显著高于对照组(P<0.05);(2)观察组患者的FVC、PEF、FEV1、MMEF的改善率均显著高于对照组(P<0.05);(3)观察组的治疗有效率显著高于对照组(P<0.05)。结论:沙美特罗氟替卡松粉吸入剂治疗儿童支气管哮喘相较于丙酸氟替卡松吸入气雾剂进行治疗,临床疗效显著,并且明显改善肺功能指数和血清炎症因子水平,值得临床推广。

Objective:To observe the efficacy of salmeterol fluticasone powder inhalation in the treatment of children with bronchial asthma and analysis of its influence on inflammatory factors,so as to provide a reference treatment plan for clinical treatment of children’s bronchial asthma.Methods:150 children with bronchial asthma treated in the hospital from January 2018 to January 2019 were selected as study subjects.They were numbered according to the order of inclusion,and were randomly divided into the control group and the observation group by the numerical random table method,with 75 cases in each group.The control group was treated with fluticasone propionate inhaled aerosol,while the treatment group was treated with salmeterol fluticasone powder inhaled aerosol.Serum inflammatory factors(CRP,EOS,IL-4,IL-10)were administered before and after treatment in the two groups,and the change rate of pulmonary function indicators in the children after treatment was determined to determine the clinical efficacy,and the above indicators were compared between the two groups.Results:(1)In the two groups after treatment with CRP,EOS,IL-4 was significantly lower than before the treatment,IL-10 was significantly higher than before the treatment(P<0.05).The CRP,EOS and IL-4 of the observation group were significantly lower than those of the control group,and the IL-10 was significantly higher than that of the control group(P<0.05).(2)The improvement rates of FVC,PEF,FEV1 and MMEF in the observation group were significantly higher than those in the control group(P<0.05).(3)The effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).Conclusion:Compared with fluticasone propionate inhaled aerosol,salmeterol fluticasone powder in the treatment of bronchial asthma in children has a higher clinical efficacy and significantly improves the pulmonary function index and serum inflammatory factor level,which is worthy of clinical promotion.