摘要
综合运用多种现代色谱技术对兰科石斛属植物石斛Dendrobium nobile Lindl.根中的化学成分进行了系统的分离纯化,从其根的乙醇提取物中分离得到了phenanobiles A~C(1~3),6,7-dihydroxy-2-methoxy-1,4-phenanthrenedione(4)和ephemeranthoquinone(5)5个菲醌类化合物.采用多种波谱技术确定了这些化合物的结构,其中化合物1~3为新的菲醌类化合物.化合物1~5的体外抗肿瘤活性评价结果表明它们对3种肿瘤细胞株(HL-60,A549以及MCF-7)显示出体外生长抑制活性.
Three new phenanthraquinones,phenanobiles A~C(1~3),together with two known phenanthraquinones 6,7-dihydroxy-2-methoxy-1,4-phenanthrenedione(4)and ephemeranthoquinone(5),were isolated from the root of Dendrobium nobile.Their structures were elucidated using comprehensive spectroscopic methods.The antitumor activities of compounds 1~5 were evaluated against three cancer cell lines(HL-60,A549 and MCF-7).Compounds 1~5 exhibited inhibitory effects against three cancer cell lines HeLa,MCF-7 and A549 in vitro.
作者
刘英豪
林芳霞
谭银丰
杨静雨
张斌
周学明
宋鑫明
Liu Yinghao;Lin Fangxia;Tan Yinfeng;Yang Jingyu;Zhang Bin;Zhou Xueming;Song Xinming(Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158;Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs,Hainan Medical College,Haikou 570216;Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2021年第5期2112-2115,共4页
Chinese Journal of Organic Chemistry
基金
海南省自然科学基金(No.218QN234)
海南省热带药用植物研究开发重点实验室开放研究(No.KF202002)
国家自然科学基金(Nos.21662012,41866005)
教育部创新研究团队(No.IRT-16R19)资助项目.
关键词
石斛属
石斛
菲醌
抗肿瘤活性
Dendrobium
Dendrobium nobile
phenanthraquinone
antitumor activity
