摘要
Owing to the paucity of donor organs and their acute rejection by the immune system after transplantation,advanced organ failure is one of the major challenges faced by the medical community.Static culturing used for synthesising tissues and organs cannot simulate the in vivo mechanical and biochemical signals;therefore,such artificial organs fail to maintain effective functional activity following transplantation.Tissue engineering can overcome these hurdles by successfully enabling regeneration of tissues and organs in vitro.Bioreactors are pivotal in the development and generation of engineered biological products.They simulate the in vivo microenvironment of tissue growth while also providing various mechanical stimuli and biochemical signals to stem cells to effectively generate transplantable organs or tissues.Various designs and types of bioreactors,their applications,and future research prospects are summarised,which promote functional tissue engineering.
作者
WANG Wenhao
DENG Qian
LI Tao
LIU Yuehua
LIU Yang
SUN Yeye
DENG Changxu
ZHOU Xiaojun
MA Zhenjiang
QIANG Lei
WANG Jinwu
DAI Kerong
王文豪;邓迁;李涛;刘月华;刘洋;孙叶叶;邓昌旭;周小军;马振江;强磊;王金武;戴尅戎(College of Medicine,Southwest Jiaotong University,Chengdu,610031,China;Shanghai Key Laboratory of Orthopaedic Implants,Department of Orthopaedic Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200011,China;Department of Obstetrics and Gynecology,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou,450052,China;Hunan Polytechnic of Environment and Biology,Hengyang,Hunan,422000,China;College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai,201620,China)
基金
the National Key Research and Development Program of China(No.2018YFB1105600)。
