抗抑郁药物对体重影响机制的研究进展

Research progress on the mechanism of antidepressants on body weight

抗抑郁药物是抑郁症的一线治疗选择。然而,大多数抗抑郁药都有许多不良反应,包括影响心脏代谢和增加体重。抗抑郁药存在不同的体重增加风险,同一类别的抗抑郁药物也存在差异。目前的研究表明,组胺和5-羟色胺在体重增加不良反应中起到关键作用,超出了以往认为的促进食欲途径。关注体重增加这一不良反应是选择抗抑郁药的一个重要因素。现就目前常用抗抑郁药物对体重影响的机制进行综述。

Antidepressants are the first-line treatment choice for depression.However,most antidepressants have many adverse reactions,including cardiac metabolic effects and weight gain.Antidepressants have different risks of weight gain,and there are differences in the same category of antidepressants.Current research results show that histamine and serotonin play a key role in adverse reactions of weight gain,beyond the previously thought ways of promoting appetite.Therefore,paying attention to the side effect of weight gain is an important factor in choosing antidepressants.This article reviews the mechanism of the effect of commonly used antidepressants on body weight.