轻度认知功能障碍与阿尔茨海默病患者感觉障碍及其电生理改变研究进展

Reviews of sensory disturbance and related electrophysiological change in Alzheimer disease and mildcognitive impairment

阿尔茨海默病(AD)是最常见的中枢神经退行性疾病之一,常隐匿起病,目前尚缺乏有效的治疗手段。轻度认知障碍(MCI)是介于正常衰老与痴呆之间的一种认知功能损害状态,部分MCI可发展成为AD。AD的核心临床症状主要为记忆障碍、认知功能障碍、人格和行为改变。多项研究表明AD可能伴随有感觉障碍,如嗅觉、视觉、听觉等,其中嗅觉障碍可能是MCI或AD早期的临床症状之一,并且在MCI及AD患者中可出现感觉相关电生理改变。现就MCI及AD患者感觉障碍及其电生理研究进行综述。

Alzheimer disease(AD)is one of the most common neurodegenerative diseases,which often has an insidious onset and is lack of effective treatments.Mild cognitive impairment(MCI),which partly can develop into AD,is a state of cognitive impairment between normal aging and dementia.The major core clinical symptoms of AD include memory impairment,cognitive dysfunction,changes of personality and behavior.Many studies have shown that AD may be accompanied by sensory disturbances,such as smell,vision,hearing,etc.,among which olfactory disturbances may be one of the early clinical symptoms of MCI or AD,and MCI and AD patients may have sensation-related electrophysiological changes.This article reviews the progress of sensory disturbance and related electrophysiological change in MCI and AD patients.