脑小血管病与血清同型半胱氨酸相关性的研究进展

Research progress on the relationship between cerebral small vessel disease and serum homocysteine

血清同型半胱氨酸水平升高是血管内皮功能障碍的危险因素,与大动脉内皮细胞相比,小动脉内皮细胞对血清同型半胱氨酸水平更具敏感性。因此研究脑小血管病与血清同型半胱氨酸水平的相关性有重要意义。国内外许多研究证实同型半胱氨酸水平与脑小血管病的影像学亚型、认知功能障碍、痴呆症的发生发展相关,现综述脑小血管病与血清同型半胱氨酸水平相关的研究进展,为脑小血管病的临床诊治提供依据。

Increased serum homocysteine level is a risk factor for vascular endothelial dysfunction.It has a similar pathological process to the endothelial function damage of large arteries and small arteries.Compared with large artery endothelial cells,small artery endothelial cells were more sensitive to serum homocysteine.Therefore,it is important to study the correlation between cerebral small vessel disease and serum homocysteine level.Many studies in China and abroad have confirmed that the level of homocysteine is related to the imaging subtypes of cerebral small vessel disease,cognitive dysfunction,and the occurrence and development of dementia.This article reviews the relationship between cerebral small vessel disease and serum homocysteine level,which is of great significance to the clinical diagnosis and treatment of cerebral small vessel disease.