炙甘草汤合血府逐瘀汤加减治疗冠心病合并糖尿病临床研究

Clinical Study on Modified Zhigancao Tang Combined with Xuefu Zhuyu Tang for Coronary Heart Disease Complicated with Diabetes

目的:观察炙甘草汤合血府逐瘀汤加减治疗冠心病合并糖尿病的临床疗效。方法:回顾性选取冠心病合并糖尿病患者117例,按治疗方法不同分为对照组53例和研究组64例。对照组给予常规西药治疗,研究组在对照组基础上给予炙甘草汤合血府逐瘀汤加减治疗。比较2组临床疗效、血糖水平、心绞痛症状及心功能。结果:研究组临床总有效率为95.31%,高于对照组79.25%,差异有统计学意义(P<0.05)。治疗前,2组心绞痛频率、每次心绞痛持续时间、左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)、左室射血分数(LVEF)、B型利尿钠肽(BNP)水平比较,差异均无统计学意义(P>0.05)。治疗后,2组心绞痛频率、每次心绞痛持续时间、LVEDV、LVESV、BNP水平较治疗前降低,LVEF较治疗前升高(P<0.05);且观察组心绞痛频率、每次心绞痛持续时间、LVEDV、LVESV、BNP水平低于对照组,LVEF高于对照组(P<0.05)。治疗前,2组空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)水平比较,差异无统计学意义(P>0.05)。治疗后,2组FBG、TC、TG、LDL水平较治疗前降低,HDL水平较治疗前升高(P<0.05);且观察组FBG、TC、TG、LDL水平低于对照组,HDL水平高于对照组(P<0.05)。结论:炙甘草汤合血府逐瘀汤加减治疗冠心病合并糖尿病患者,可有效改善患者心绞痛症状及心功能,改善血糖、血脂水平,提高临床疗效。

Objective:To observe the clinical effect of Zhigancao tang combined with Xuefu Zhuyu tang on coronary heart disease complicated with diabetes. Methods:A total of 117 patients with coronary heart disease complicated with diabetes were retrospectively selected and divided into the control group(53 cases) and the study group(64 cases) according to different treatment methods. The control group was treated with conventional western medicine,and the study group was additionally treated with Zhigancao tang combined with Xuefu Zhuyu tang based on the treatment of the control group. The clinical effect,level of blood glucose, symptoms of angina pectoris and the heart function were compared between the two groups.Results: The total effective rate was 95.31% in the study group, higher than that of 79.25% in the control group, the difference being significant(P<0.05). Before treatment, there was no significant difference in the comparison of levels of angina frequency, angina duration, left ventricular end-diastolic volume(LVEDV), left ventricular end-systolic volume(LVESV), left ventricular ejection fraction(LVEF) and B-type diuretic natriuretic peptide(BNP) between the two groups(P>0.05). After treatment, the levels of angina frequency, angina duration, LVEDV, LVESV and BNP in the two groups were decreased when compared with those before treatment,while the LVEF levels were increased(P<0.05).The levels of angina frequency,angina duration,LVEDV,LVESV and BNP in the observation group were lower than those in the control group, and the LVEF level was higher(P<0.05). Before treatment, there was no significant difference in the comparison of the levels of fasting blood glucose(FBG),total cholesterol(TC),triglyceride(TG),low-density lipoprotein(LDL)and high-density lipoprotein(HDL) between the two groups(P>0.05).After treatment,the levels of FBG,TC,TG and LDL in both groups were decreased when compared with those before treatment,while the levels of HDL were increased(P<0.05).The levels of FBG,TC,TG and LDL in the observation group were lower than those in the control group,and the level of HDL was higher(P<0.05). Conclusion:Modified Zhigancao tang combined with Xuefu Zhuyu tang for patients with coronary heart disease complicated with diabetes, can effectively improve the symptoms of angina pectoris, the heart function,the levels of blood glucose and lipid,as well as clinical effect.