卵巢癌根治术后患者HE4和CA125水平变化与其预后的相关性

Study on the Correlation between the Changes of HE4 and CA125 Levels and the Prognosis of Patients after Radical Ovarian Cancer

目的检测卵巢癌根治术前后患者血清中HE4和CA125水平的变化情况,并进一步分析其与患者预后的相关性。方法选择行卵巢癌根治术的200例卵巢癌患者作为实验组,分别于手术前和手术后取患者血清;另以同期于体检中心进行健康体检的109例健康者为对照组并采集血样,酶联免疫吸附试验检测2组研究对象血清中HE4和CA125水平,并进行比较,从而进一步分析血清HE4和CA125水平变化与患者预后的相关性。结果(1)术前1 d和术后3 d实验组患者血清中HE4和CA125水平均较对照组显著升高。(2)术前1 d及术后3 d~6月,实验组不同分期患者血清中HE4和CA125水平均存在显著差异(P<0.05);与Ⅰ期患者相比,Ⅱ期和Ⅲ期患者血清中HE4和CA125水平均显著升高(P<0.05),且Ⅲ期患者血清中HE4、CA125水平也较Ⅱ期患者显著升高(P<0.05);术后3 d~6月不同分期患者血清中HE4和CA125水平均显著低于术前1 d(P<0.05)。(3)术后1月~6月,不同分期患者术后有效率和术后复发率均存在显著差异(P<0.05)。与Ⅰ期患者相比,Ⅱ期和Ⅲ期患者术后有效率均较低(P<0.05),而Ⅱ期和Ⅲ期患者相比差异不具有统计学意义(P>0.05);Ⅲ期患者术后复发率均较Ⅰ期和Ⅱ期患者显著增加,而Ⅰ期和Ⅱ期患者相比,差异不具有统计学意义(P>0.05)。(4)患者血清HE4和CA125水平与其预后复发均存在显著正相关关系(=0.632、0.580,P均<0.001)。结论血清中HE4和CA125水平变化与卵巢癌的发病及进展密切相关,且与患者预后复发均存在显著正相关关系,因而其对患者治疗效果及预后具有一定的评估价值。

Objective To detect the changes of serum HE4 and CA125 levels in patients before and after radical ovarian cancer surgery,and further analyze their correlation with the patient’s prognosis.Methods 200 cases of ovarian cancer patients undergoing radical ovarian cancer surgery were selected as the experimental group,and serum was taken before and after the operation.In addition,109 healthy people who underwent physical examination at the physical examination center during the same period were selected as the control group and their blood samples were collected.Enzyme-linked immunosorbent assay was used to detect and compare the levels of HE4 and CA125 in the serum of the 2 groups of subjects,so as to further analyze the correlation between changes in serum levels of HE4 and CA125 and patient prognosis.Results(1)The serum levels of HE4 and CA125 in the experimental group were significantly higher than those in the control group 1 day before operation and 3 days after operation.(2)1 day before operation and 3 days to 6 months after operation,there were significant differences in serum HE4 and CA125 levels in patients of different stages(P<0.05);and compared with stage I patients,the levels of HE4 and CA125 in the serum of stage II and III patients were significantly higher(P<0.05),and the above 2 indexes in the serum of stage III patients were also significantly higher than those of stage II patients(P<0.05);the serum levels of HE4 and CA125 in patients with different stages from 3 d to 6 months after operation were significantly lower than those of 1 day before operation(P<0.05).(3)1 to 6 months after surgery,there were significant differences in the postoperative effective rate and postoperative recurrence rate of patients with different stages(P<0.05).Compared with stage I patients,the postoperative effective rates of stage II and stage III patients were significantly increased(P<0.05),but the difference between the 2 groups was not statistically significant(P>0.05);The postoperative recurrence rate of stageⅢpatients was significantly higher than that of stageⅠand stageⅡpatients,and the difference between the 2 groups was not statistically significant(P>0.05).(4)The serum HE4 and CA125 levels of the patients were significantly positively correlated with their prognosis and recurrence(r=0.632,0.580,both P<0.001).Conclusion The changes of serum HE4 and CA125 levels in ovarian patients are closely related to the incidence and progression of the tumor,and there is a significant positive correlation between the prognosis and recurrence of the tumor.Therefore,it has a certain evaluation value for the treatment effect and prognosis of patients.