骨代谢过程中白细胞介素1的参与作用及调控机制

Participation and regulatory mechanism of interleukin-1 during bone metabolism

背景:研究发现白细胞介素1的两种生物活性相似的同工型白细胞介素1α和白细胞介素1β对骨的代谢会产生重大影响,研究表明它们具有诱导成骨细胞或破骨细胞分化的能力。目的:综述目前已知相关文献,总结白细胞介素1与成骨细胞或破骨细胞的关系,了解白细胞介素1在骨代谢中的作用机制,为新的成骨方案提供理论参考。方法:检索中国知网和PubMed数据库白细胞介素1在成骨细胞与破骨细胞中的作用机制相关的文献,最终共纳入74篇文章进行综述分析。结果与结论:白细胞介素1作为人体内的多功能细胞因子,无论对成骨代谢还是破骨代谢过程都产生着深远的影响。(1)白细胞介素1主要与破骨细胞的分化、激活、生存密切相关,不仅可以直接通过RANKL/RANK直接作用发挥破骨效应,也可以通过上调前列腺素E2和巨噬细胞集落刺激因子从而减少骨保护素的产生间接刺激破骨细胞生成。此外,破骨细胞多核化成熟也与白细胞介素1密切相关。(2)有研究发现白细胞介素1β不仅会对成骨细胞分化产生影响,也可以通过影响成骨相关蛋白间接调控成骨代谢。(3)最近的研究发现白细胞介素1β可以调控血凝块的结构从而影响早期骨愈合过程,这又为研究白细胞介素1提供一个可行的参考。(4)因此,该综述有望进一步了解白细胞介素1参与骨代谢的具体机制,为良好的成骨策略提供理论参考。

BACKGROUND:Two isoforms of interleukin-1,interleukin-1αand interleukin-1β,which have similar bioactivity,have been shown to have significant effects on bone metabolism and have been shown to induce differentiation of osteoblasts or osteoclasts.OBJECTIVE:To summarize the relationship between interleukin 1 and osteoblasts or osteoclasts,and to understand the mechanism of interleukin 1 in bone metabolism,so as to provide theoretical reference for new osteogenic programs.METHODS:CNKI and PubMed were searched for articles related to the mechanism of interleukin-1 in osteoblasts and osteoclasts.A total of 74 articles were included for review analysis.RESULTS AND CONCLUSION:Interleukin 1,as a multifunctional cytokine in vivo,has a profound effect on both osteogenic and osteoclastic metabolism.(1)Interleukin 1 is closely related to the differentiation,activation and survival of osteoclasts.It can not only exert osteoclast effect directly through RANKL/RANK,but also reduce the production of osteoprotectin and indirectly stimulate osteoclast formation by upregulation of prostagland E2 and macrophage colony stimulating factor.In addition,the multinucleated maturation of osteoclasts was also closely related to interleukin 1.(2)It has been found that interleukin 1βnot only affects the differentiation of osteoblasts,but also indirectly regulates osteogenic metabolism by affecting osteoblast-related proteins.(3)Recent studies have shown that interleukin 1βcan regulate the structure of blood clots and thus affect early bone healing,which provides a useful reference for our study of interleukin 1β.(4)Therefore,this review is expected to further understand the specific mechanism of interleukin 1 involved in bone metabolism and provide theoretical reference for good osteogenesis strategies.