急性缺血性脑卒中患者衰弱与认知功能障碍的相关性

Correlation between frailty and cognitive dysfunction in patients with acute ischemic stroke

目的探讨急性缺血性脑卒中患者衰弱与认知功能障碍的相关性。方法选择2019年10月—2020年6月于首都医科大学附属北京朝阳医院神经内科就诊的127例急性缺血性脑卒中患者,应用埃德蒙顿衰弱量表(EFS)评价其衰弱情况。根据其是否发生衰弱分为衰弱组(51例)和非衰弱组(76例)。收集两组一般资料。应用蒙特利尔认知评估量表(MoCA)评价两组的认知功能。结果衰弱组年龄、血糖水平、合并糖尿病占比、合并高血压占比均高于非衰弱组,MoCA总分及各领域得分均低于非衰弱组,差异有统计学意义(均P<0.05)。相关分析显示,EFS总分与MoCA总分(r=-0.491,P<0.001)、视空间/执行功能得分(r=-0.444,P<0.001)、命名得分(r=-0.237,P<0.001)、记忆力得分(r=-0.364,P<0.001)、注意力得分(r=-0.350,P<0.010)、语言功能得分(r=-0.238,P=0.007)、抽象能力得分(r=-0.202,P=0.023)和定向力得分(r=-0.229,P=0.010)均呈负相关。结论急性缺血性脑卒中患者易发生衰弱和认知功能障碍,衰弱状态可影响认知功能障碍的发生。

Objective To explore the correlation between frailty and cognitive dysfunction in patients with acute ischemic stroke.Methods A total of 127 patients with acute ischemic stroke admitted to Beijing Chaoyang Hospital of Capital Medical University from October 2019 to June 2020 were selected.Edmonton frailty scale(EFS)was used to evaluate their frailty,and they were divided into frailty group(51 cases)and non-frailty group(76 cases)according to whether frailty occurred.General data of the two groups were collected,and the cognitive function of the two groups was evaluated using the Montreal cognitive assessment scale(MoCA).Results The age,blood glucose levels,proportion of diabetes and proportion of hypertension in the frailty group were higher than those in the non-frailty group,and the total score of MoCA and scores of all fields were lower than those in the non-frailty group,the differences were statistically significant(all P<0.05).Correlation analysis showed that total EFS score was negatively correlated with total MoCA score(r=-0.491,P<0.001),visuospatial/executive function score(r=-0.444,P<0.001),naming score(r=-0.237,P<0.001),memory score(r=-0.364,P<0.001),attention scores(r=-0.350,P<0.001),language function scores(r=-0.238,P=0.007),abstract ability scores(r=-0.202,P=0.023),and orientation scores(r=-0.229,P=0.010)negatively correlated.Conclusion Patients with acute ischemic stroke are prone to frailty and cognitive dysfunction,the frailty can affect the occurrence of cognitive dysfunction.