定眩颗粒联合天麻素治疗椎基底动脉供血不足的效果

Effect of Dingxuan Granules combined with Gastrodin in the treatment of vertebro-basilar artery insufficiency

目的探讨定眩颗粒联合天麻素治疗椎基底动脉供血不足的效果。方法选择2018年1月—2019年12月安徽省芜湖市中医医院接诊的100例椎基底动脉供血不足患者,按照随机数字表法将其分为观察组和对照组,每组各50例。对照组在常规治疗基础上给予天麻素治疗,观察组在对照组基础上联合定眩颗粒治疗,两组均持续治疗14 d。比较两组治疗后的临床疗效、治疗前后左侧椎动脉(LVA)、右侧椎动脉(RVA)、基底动脉(BA)血流速度和基底节区脑血流量(CBF)、脑血容量(CBV)、平均通过时间(MTT)的变化及治疗期间不良反应发生率。结果观察组临床总有效率高于对照组,差异有统计学意义(P<0.05);两组LVA、RVA、BA血流速度和基底节区CBF、CBV均高于治疗前,MTT均短于治疗前,且观察组LVA、RVA、BA血流速度和基底节区CBF、CBV高于对照组,MTT短于对照组,差异均有统计学意义(均P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论定眩颗粒联合天麻素治疗椎基底动脉供血不足的效果明显,且安全性好,值得应用推广。

Objective To investigate the effect of Dingxuan Granules combined with Gastrodin in the treatment of vertebro-basilar artery insufficiency.Methods A total of 100 patients with vertebro-basilar artery insufficiency admitted to Wuhu Hospital of Traditional Chinese Medicine in Anhui Province from January 2018 to December 2019 were selected and they were divided into observation group and control group according to random number table method,with 50 patients in each group.The control group was treated with Gastrodin on the basis of conventional treatment,and the observation group was treated with Dingxuan Granules on the basis of the control group.Both groups were treated continuously for 14 days.The clinical efficacy after treatment,the changes of blood flow velocities of left vertebral artery(LVA),right vertebral artery(RVA),basilar artery(BA),cerebral blood flow(CBF)in basal ganglia region,cerebral blood volume(CBV),mean transit time(MTT)before and after treatment were compared between the two groups,and the incidence of adverse reactions during treatment were compared between the two groups.Results The total clinical effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The blood flow velocities of LVA,RVA,BA and basal ganglia region CBF and CBV in the two groups were higher than before treatment,and the MTT was shorter than before treatment.The blood flow velocities of LVA,RVA,BA and basal ganglia region CBF and CBV in the observation group were higher than those in the control group,and the MTT was shorter than that in the control group,with statistical significance(all P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Dingxuan Granules combined with Gastrodin in the treatment of vertebro-basilar artery insufficiency has obvious effect and good safety,which is worthy of application and promotion.