基于数据挖掘探析中医治疗肺腺癌用药规律

Analysis on medication rule of traditional Chinese medicine in the treatment of lung adenocarcinoma based on data mining

目的探析中医治疗肺腺癌的组方用药规律。方法检索中国知网、万方数据库2010年1月—2020年11月采用中医疗法治疗肺腺癌的病案,提取组方信息后输入Excel 2013建立数据库,采用SPSS 23与SPSS Modeler 18对中药功效、归经、关联规则、聚类情况进行数据挖掘。结果符合条件病案96例,涉及药物193味。按功效分为13类,使用较频繁的前3类为补虚药、活血化瘀药、化痰药;药物以入肺、脾、胃、肝经为主;关联性较强的药物组合为清热解毒药配合补虚药、活血化瘀药,以此形成四大聚类,常用的药物组合有黄芪、白术、白花蛇舌草相互配伍。结论中医治疗肺腺癌常依据“标本兼治,补气化瘀,五脏同调”的基本方针,配伍益气活血、消瘀散结、健脾化痰相关中药。

Objective To explore the prescriptions rule of traditional Chinese medicine in the treatment of lung adenocarcinoma.Methods The medical records of lung adenocarcinoma treated with traditional Chinese medicine were collected by searching CNKI and Wanfang database from January 2010 to November 2020.The group information was extracted and inputed into excel 2013 to establish a database.SPSS 23 and SPSS Modeler 18 were used to mine the efficacy,meridian tropism,association rules and clustering of traditional Chinese medicine.Results There were 96 eligible medical records,involving 193 drugs.They were divided into 13 categories according to their efficacy.The first three categories were used frequently,which were tonic drugs,blood stasis-activating drugs and phlegm-resolving drugs.The medicines entering to lung,spleen,stomach and liver channels were mainly used.The combination of medicines with strong correlation were the heat-clearing and detoxifying medicine plus the tonic medicine,the bloodpromoting medicine.In this way,four major clusters were formed which were commonly used drug combinations including Astragali Radix,Atractylodis Macrocephalae Rhizoma,Hedyotis.Conclusion Traditional Chinese medicine treating lung adenocarcinoma is often based on the basic principle of“treating both the symptoms and the root causes,invigorating qi and removing blood stasis,and harmonizing the five zang organs”,which is combined with Chinese herbs related to supplementing qi and activating blood circulation,eliminating blood stasis and resolving stagnation,strengthening spleen and resolving phlegm.