基于数据挖掘的柴胡加龙骨牡蛎汤化裁治疗失眠的中医证候分布特点及组方规律分析

Analysis of TCM syndrome distribution characteristics and prescription pattern of Chaihu and Longgu Muli decoction for insomnia based on data mining

目的:基于数据挖掘技术,总结归纳使用柴胡加龙骨牡蛎汤化裁辨证论治失眠的中医证候的分布特点,分析具有完整药物组成、疗效确切的处方的核心药物组成及配伍规律。方法:在数据库中收集自1999年以来文献中柴胡加龙骨牡蛎汤化裁治疗失眠有关的中医文献资料,从合乎入选标准的文献中提取患者性别、年龄、证候及组方药物,录入Excel,构建数据库,统计其出现频次及百分比,分析药物功效及归经。结果:柴胡加龙骨牡蛎治疗失眠的证型主要集中在肝郁气滞、痰热扰心、肝郁化火、肝胆郁热、肝火扰心等5型,分别占16.18%(33/134)、8.82%(18/134)、8.33%(17/134)、7.84%(16/134)、7.84%(16/134)。处方中所用药物频次前六位分别为柴胡、龙骨、牡蛎、半夏、黄芩及茯苓。化裁的药物从其药物功效来看,以养心安神的安神药和补气功效的补虚药为主;其次为清热燥湿、重镇安神和活血化瘀药。从药物归经角度来看,主要归为心、肝经。结论:化裁后的柴胡加龙骨牡蛎汤运用范围扩大,对多种证型的失眠均有疗效。

Objective: To summarize the traditional Chinese medicine(TCM) syndrome distribution characteristics and prescription pattern of Chaihu and Longgu Muli decoction( 柴胡加龙骨牡蛎汤) for insomnia based on data mining, and to analyze the core drug composition and compatibility rules of prescriptions with complete drug composition and accurate curative effect. Methods: TCM literature related to the treatment of insomnia with Chaihu and Longgu Muli decoction in the literature since 1999 were collected. The patient’s gender, age, syndrome, and prescription drugs were extracted from the literature that met the selection criteria and entered into Excel.A database was built and its frequency and percentage were counted. The efficacy of drugs and meridial distribution were analyzed.Results: The symptoms of insomnia treated by Chaihu and Longgu Muli decoction mainly focused on the five types of liver stagnation and Qi(气)stagnation, phlegm heat to disturb the heart, liver stagnation and fire, liver and gall stagnation fever, and liver and fire to disturb the heart, accounting for 16.18%(33/134), 8.82%(18/134), 8.33%(17/134), 7.84%(16/134) and 7.84%(16/134). The top six drugs used in the prescription were Chaihu, keel, oyster, pinellia, scutellaria baicalensis and Poria. From the point of view of its drug efficacy, the medicines used for reorganization are mainly sedatives for replenishing the heart and relieving Qi, and tonics for replenishing Qi, and the second are clearing heat and dampness, relieving heat and dampness, relieving sedation and promoting blood circulation and removing blood stasis. From the perspective of meridian, it is mainly classified as heart and liver meridian. Conclusion: The scope of application of Chaihu and Longgu Muli decoction after scalping has been expanded, and it is effective for various types of insomnia.