肿瘤微环境与乳腺癌细胞糖代谢重编程研究进展

Progress on Metabolism Reprogramming in Tumor Microenvironment of Breast Cancer

乳腺癌的进展、转移能力除了取决于肿瘤细胞的特性之外,还取决于肿瘤微环境对肿瘤细胞葡萄糖代谢的重新编程。肿瘤细胞葡萄糖代谢重编程即在氧气存在的情况下肿瘤细胞更喜欢在细胞质进行糖酵解,称为"Warburg效应"或"有氧糖酵解"。肿瘤微环境成分如肿瘤相关成纤维细胞、巨噬细胞、免疫细胞等也可发生糖代谢重编程,且两者之间相互影响促进乳腺癌的发展。全文综述了微环境主要成分与肿瘤细胞葡萄糖代谢重新编程相互作用对乳腺癌生物学和进展的重要性。

The progression,metastasis ability of breast cancer not only depends on the characteristics of tumor cells,but also on the reprogramming of glucose metabolism in tumor microenvironment.Glucose metabolism reprogramming is the glycolysis in cytoplasm of tumor cells in the presence of oxygen,it is also referred to as"Warburg effect"or"aerobic glycolysis".Tumor microenvironmental components such as tumor-associated fibroblasts,macrophages and immune cells can also undergo glucose metabolism reprogramming,and the interaction between them promotes the development of breast cancer.This article reviews the importance of the glucose metabolism reprogramming in tumor cells and in major components of the tumor microenvironment for breast cancer biology and progression.