中西医结合治疗对早期先兆流产患者的影响

Effect of integrated traditional Chinese and Western medicine on early threatened abortion and pregnancy outcome

目的探讨中西医结合治疗对早期先兆流产患者的效果及对妊娠结局的影响。方法选取2018年1月—2020年1月山东省聊城市中医医院收治的118例先兆流产患者为研究对象,依据随机数字表法分为对照组与观察组,各59例。对照组实施常规西医治疗,观察组在对照组基础上使用加味寿胎丸,治疗2个疗程。比较两组临床疗效,中医证候积分、血清激素水平、并发症及妊娠结局。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组中医证候积分比较,差异无统计学意义(P>0.05)。治疗后,两组中医证候积分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组血清人绒毛膜促性腺激素β亚单位(β-HCG)、雌二醇(E2)及孕酮(P)水平比较,差异无统计学意义(P>0.05)。治疗后,两组血清β-HCG、E2及P水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。两组并发症总发生率比较,差异无统计学意义(P>0.05)。观察组自然分娩率、新生儿体重及Apgar评分高于对照组,新生儿窒息率、早产率低于对照组,差异有统计学意义(P<0.05)。结论中西医结合治疗早期先兆流产患者的临床效果显著,可有效缓解临床症状,调节血清激素水平,同时尚未增加并发症的发生率,获得更好的妊娠结局。

Objective To investigate the effect of integrated traditional Chinese and Western medicine on early threatened abortion and the effect of pregnancy outcome.Methods A total of 118 patients with threatened abortion treated in Liaocheng Traditional Chinese Medicine Hospital from January 2018 to January 2020 were selected as study objects.According to the random number table method,they were divided into control group and observation group,with 59 cases in each group.Control group was treated with conventional Western medicine,and observation group was treated with Jiawei Shoutai Pills on the basis of control group,and the treatment lasted for 2 courses.The clinical curative effect,traditional Chinese medicine syndrome score,serum hormone level,complication and pregnancy outcome were compared between two groups.Results The total effective rate of observation group was higher than that of control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in traditional Chinese medicine syndrome score between two groups(P>0.05).After treatment,traditional Chinese medicine syndrome scores of two groups were lower than those before treatment,and observation group was lower than control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in serum levels of human chorionic gonadotrophin-βsubunit(β-HCG),estradiol(E2),and progesterone(P)between two groups(P>0.05).After treatment,the levels ofβ-HCG,E2,and P in two groups were higher than those before treatment,and observation group was higher than control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of complications between two groups(P>0.05).The birth rate,newborn weight and Apgar score of observation group were higher than those of control group,and the neonatal asphyxia rate and premature birth rate were lower than those of control group,and the differences were statistically significant(P<0.05).Conclusion The clinical effect of the treatment of early threatened abortion patients with integrated traditional Chinese and Western medicine is significant,can effectively alleviate the clinical symptoms,regulate the serum hormone level,while not increasing the incidence of complications,to obtain a better pregnancy outcome.