基于数据挖掘研究现代医家治疗阿尔茨海默病的用药规律

Research on medication rule of modern doctors in the treatment of Alzheimer disease based on data mining

目的收集整理中医药防治阿尔茨海默病中药复方的组方规律。方法计算机检索中国知网、维普数据库、万方数据库,搜索阿尔茨海默病随机对照试验,检索时间为建库至2020年10月,文献筛选得到文献数据后采用Apriori算法进行统计分析。结果共筛选出173个中药复方,涉及190味中药,药物总词频1752次,频次>40的有12味。防治阿尔茨海默病的中药大多是补虚药、活血化瘀药及化痰止咳平喘药。大多中药归肝、肾、肺、脾经,性温平、味甘苦。Apriori计算结果显示,常用2味药配伍为远志与石菖蒲配伍;常用3味药配伍为熟地、远志与石菖蒲配伍,川芎、远志与石菖蒲配伍;常用4味药配伍为丹参、熟地、远志与石菖蒲配伍。结论本研究组方规律中,远志与石菖蒲关联性最高,运用方药时可以此药对配伍为基础进行组方。

Objective To collect and sort out the prescription rules of traditional Chinese medicine in the prevention and treatment of Alzheimer disease.Methods The randomized controlled trials of Alzheimer disease were searched in CNKI,VIP database and Wanfang database.The retrieval time was limited to October 2020.The literatures were screened,and then Apriori algorithm was used for statistical analysis.Results A total of 173 Chinese herbal compounds were screened out,involved 190 Chinese herbal medicines.The total frequency of Chinese herbal medicines was 1752,and 12 of them were more than 40.Traditional Chinese medicine for the prevention and treatment of Alzheimer disease is mostly tonifying deficiency drugs,promoting blood circulation and removing blood stasis drugs and phlegm,relieving cough and asthma drugs.Most of them belong to liver,kidney,lung and spleen meridians,with mild nature and sweet and bitter taste.The results of Apriori calculation showed that the compatibility of two herbs were Polygalae Radix and Acori Tatarinowii Rhizoma.The common compatibility of three herbs were Rehmanniae Radix Praeparata,Polygalae Radix and Acori Tatarinowii Rhizoma;Chuanxiong Rhizoma,Polygalae Radix and Acori Tatarinowii Rhizoma.The common compatibility of four herbs were Salviae Miltiorrhizae Radix et Rhizoma,Rehmanniae Radix Praeparata,Polygalae Radix and Acori Tatarinowii Rhizoma.Conclusion In this study,Polygalae Radix and Acori Tatarinowii Rhizoma have the highest correlation,and the prescription can be made based on the compatibility of this drug pair.