安列克治疗宫缩乏力性产后出血的有效性与安全性研究

Clinical Effects and Safety of Carboprost Tromethamine Injection in Uterine Inertia Women with Postpartum Hemorrhage

目的:研究安列克应用于宫缩乏力性产后出血的有效性和安全性。方法:选择2017年6月—2019年6月期间我院收治的70例宫缩乏力性产后出血产妇进行研究,按数字表法随机分为两组,每组35例,在子宫按摩的基础上,给予对照组缩宫素治疗,给予观察组安列克治疗,观察对比两组产妇产后出血情况、临床效果、安全性、生活质量等。结果:产后2 h和产后24 h出血量,对照组分别为(642.03±96.78)mL、(753.81±112.59)mL,观察组分别为(503.97±61.58)mL、(616.45±73.12)mL,差异均有统计学意义(P<0.05);观察组治疗有效率为97.14%,对照组为80%(P<0.05),两组恶心、腹泻、乏力等不良反应均较小,且差异无统计学意义(P>0.05);治疗后,两组患者的生活质量总评分均明显升高,与治疗前比较差异有统计学意义(P<0.05),且观察组生活质量评分(90.16±1.27)分高于对照组(74.81±3.77)分,差异有统计学意义(P<0.05)。结论:宫缩乏力性产后出血在子宫按摩的同时给予安列克治疗,能够快速促进子宫收缩,有效控制出血,是一种安全有效的治疗方法,不仅有效降低产妇死亡风险,还可改善患者生活质量,具有重要的临床研究意义。

Objective: To discuss the treatment effects and safety of carboprost tromethamine injection in uterine inertia women with postpartum hemorrhage. Methods: A total of 70 cases of postpartum hemorrhage due to uterine atony treated in our hospital from June 2017 to June 2019 were randomly divided into two groups: 35 cases in each group and 35 cases in each group, the Observation Group was treated with Alek, and the postpartum hemorrhage, clinical effect, safety, quality of life and so on were observed and compared. Results: 2-hour and 24-hour postpartum bleeding volume in the observation group were(503.97±61.58)ml and(616.45±73.12) ml, which were significantly smaller than those in the control group [(642.03±96.78)ml,(753.81±112.59) ml](P < 0.05);effective treatment rate in the observation group and control group was 97.14%and 80%(P < 0.05);incidences of adverse reactions like nausea, diarrhea and weakness between groups showed no statistically significant difference(P>0.05). After treatment, the total score of Qol in the two groups was significantly higher than that before treatment(P < 0.05), and the score of qol in the observation group(90.16±1.27) was higher than that in the control group(74.81±3.77), the difference was statistically significant(P < 0.05). Conclusion: Treatment of postpartum hemorrhage due to uterine atony with Alek therapy in combination with uterine massage can rapidly promote uterine contraction and effectively control bleeding. It is a safe and effective treatment method, which not only effectively reduces the risk of maternal death, it can also improve the quality of life of patients and has important clinical research significance.