肠道微生态失衡与癫痫发生的相关性研究

Study on the relationship between intestinal microecological imbalance and epilepsy

目的:研究肠道微生态失衡与癫痫发生的相关性。方法:2018年1月-2019年9月收治癫痫患者12例,分为癫痫控制组和难治性癫痫组,同时选取健康人作为对照组。比较三组粪便标本的肠道微生态菌群生物学、微生物多样性及组间物种差异。结果:对照组肠Chaol指数显著高于癫痫控制组及难治性癫痫组,差异有统计学意义(P<0.05);三组Shannon指数比较,差异无统计学意义(P>0.05)。结论:癫痫发生与患者肠道微生物失衡具有相关性,在临床上可以通过调节患者肠道微生态环境,控制癫痫的发生。

Objective:To study the correlation between the imbalance of intestinal microecology and the occurrence of epilepsy.Methods:From January 2018 to September 2019,12 patients with epilepsy were selected,they were divided into the epilepsy control group and the refractory epilepsy group,and healthy people were selected as the control group.The biology,microbial diversity and species differences of the intestinal microbiota of the stool specimens of the three groups of patients were compared.Results:The intestinal Chaol index of the control group was significantly higher than that of the epilepsy control group and the refractory epilepsy group,the difference was statistically significant(P<0.05).The Shannon index of the three groups was not statistically significant(P>0.05).Conclusion:The occurrence of epilepsy is related to the imbalance of intestinal microbes in patients.Clinically,the occurrence of epilepsy can be controlled by adjusting the intestinal microecological environment of patients.