高血压合并冠状动脉粥样硬化性心脏病患者的临床观察

Observation on clinical treatment of patients with hypertension and coronary atherosclerotic heart disease

目的:观察药物治疗高血压合并冠状动脉粥样硬化性心脏病的效果。方法:2019年1月-2020年10月收治高血压合并冠状动脉粥样硬化性心脏病患者118例,随机分为两组,各59例。两组患者均给予氨氯地平和阿托伐他汀钙,对照组给予依那普利治疗,观察组给予缬沙坦治疗,比较两组治疗效果。结果:两组治疗总有效率及不良反应发生率比较,差异无统计学意义(P>0.05);两组治疗后血压水平均得到明显改善,且改善效果无明显差异,差异无统计学意义(P>0.05)。结论:在氨氯地平和阿托伐他汀钙基础上分别配合依那普利和缬沙坦治疗高血压合并冠状动脉粥样硬化性心脏病,均可获取理想的效果,且具有较好的安全性,可灵活用药。

Objective:To discuss the clinical treatment of hypertension complicated with coronary atherosclerotic heart disease.Methods:From January 2019 to October 2020,118 cases of patients with hypertension and coronary atherosclerotic heart disease were enrolled,they were randomly divided into two groups with 59 cases in each group.Both groups of patients were given amlodipine and atorvastatin calcium.The control group was treated with enalapril.The observation group was treated with valsartan.The therapeutic effects between the two groups was compared.Results:The total effective rate of treatment and the incidence of adverse reaction were compared between the two groups,the differences were not statistically significant(P>0.05).The blood pressure level of the two groups was obviously improved after treatment,but the effect of improvement was significantly different,the difference was not statistically significant(P>0.05).Conclusion:By combining amlodipine and atorvastatin calcium with enalapril and valsartan respectively in the treatment of patients with hypertension and coronary atherosclerotic heart disease,both can obtain ideal effects,with good safety,which can be used flexibly.