金骨莲胶囊联合硫酸氨基葡萄糖和对乙酰氨基酚治疗膝骨性关节炎的临床研究

Clinical study on Jingulian Capsules combined with glucosamine sulphate and paracetamol in treatment of knee joint osteoarthritis

目的探讨金骨莲胶囊联合硫酸氨基葡萄糖胶囊和对乙酰氨基酚片治疗膝骨性关节炎的临床疗效。方法选取2019年1月—2020年1月商丘市第一人民医院确诊并接受治疗的88例膝骨性关节炎患者,按照随机数字表法分为对照组和治疗组,每组各44例。对照组口服硫酸氨基葡萄糖胶囊,500mg/次,3次/d;同时口服对乙酰氨基酚片,0.3g/次,3次/d。治疗组在对照组治疗的基础上口服金骨莲胶囊,0.5 g/次,3次/d。两组连续治疗8周。观察两组临床疗效,比较两组的骨关节指数(WOMAC)评分、Lysholm膝关节评分、疼痛程度和血清指标。结果治疗后,治疗组的总有效率高于对照组,但差异无统计学意义。治疗后,两组WOMAC评分较治疗前降低,Lysholm膝关节评分较治疗前升高,差异有统计学意义(P<0.05),且治疗组WOMAC评分低于对照组,Lysholm膝关节评分高于对照组,差异有统计学意义(P<0.05)。相较于治疗前,治疗4、8周两组视觉模拟评分法(VAS)评分逐渐降低,差异有统计学意义(P<0.05),且治疗4、8周治疗组VAS评分均低于同期对照组,差异有统计学意义(P<0.05)。治疗后,两组转化生长因子β1(TGF-β1)水平较治疗前升高,而血管内皮生长因子(VEGF)水平较治疗前降低,差异有统计学意义(P<0.05),且治疗组TGF-β1水平高于对照组,而VEGF水平低于对照组,差异有统计学意义(P<0.05)。结论膝骨性关节炎患者在硫酸氨基葡萄糖胶囊和对乙酰氨基酚片治疗的基础上联合使用金骨莲胶囊可以促进膝关节功能恢复,改善膝骨性关节炎病情和减轻疼痛程度,提升抗炎效果,且安全性好。

Objective To explore the value of Jingulian Capsules combined with Glucosamine Sulfate Capsules and Paracetamol Tablets in treatment of knee joint osteoarthritis. Methods Patients(88 cases) with knee joint osteoarthritis in Shangqiu First People’s Hospital from January 2019 to January 2020 were randomly divided into control and treatment groups, and each group had 44 cases. Patients in the control group were po administered with Glucosamine Sulfate Capsules, 500 mg/time, three times daily. And patients in the control group were also po administered with Paracetamol Tablets, 0.3 g/time, three times daily. Patients in the treatment group were po administered with Jingulian Capsules on the basis of the control group, 0.5 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and WOMAC scores, Lysholm knee scores, pain degree, and serum indexes in two groups were compared. Results After treatment, the total effective rate of the treatment group was higher than that of the control group, but the difference was not statistically significant. After treatment, the WOMAC score in two groups were decreased, but the Lysholm knee score in two groups were increased, and the difference was statistically significant(P < 0.05). After treatment, the WOMAC score in the treatment group was lower than that in the control group, while the Lysholm knee score in the treatment group was higher than that in the control group, and the difference was statistically significant(P < 0.05). Compared with before treatment, the VAS score of two groups were decreased gradually at 4 and 8 weeks of treatment, and the difference was statistically significant(P < 0.05). After treatment, the VAS score of the treatment group was lower than that of the control group at 4 and 8 weeks of treatment, and the difference was statistically significant(P < 0.05). After treatment, the level of TGF-β1 in two groups was higher than that before treatment, but the level of VEGF in two groups was lower than that before treatment, and the difference was statistically significant(P < 0.05). The level of TGF-β1 in the treatment group was higher than that in the control group, but the level of VEGF was lower than that in the control group, and the difference was statistically significant(P < 0.05). Conclusion The combined use of Jingulian Capsules in treatment of patients with knee joint osteoarthritis on the basis of Glucosamine Sulfate Capsules and Paracetamol Tablets can improve the anti-inflammatory effect, promote the recovery of knee joint function, improve the condition of knee joint osteoarthritis and reduce the degree of pain, with good safety.