天芪降糖胶囊联合达格列净治疗2型糖尿病的临床研究

Clinical study on Tianqi Jiangtang Capsules combined with dagliejing in treatment of type 2 diabetes mellitus

目的探讨天芪降糖胶囊联合达格列净片治疗2型糖尿病的临床疗效。方法回顾性分析2019年8月—2020年9月天津医科大学第二医院收治的134例2型糖尿病患者临床资料,采用随机数字表分成对照组和治疗组,每组各67例。对照组口服达格列净片,10 mg/次,1次/d;治疗组在对照组基础上口服天芪降糖胶囊,5粒/次,3次/d。两组患者治疗8周。观察两组患者临床疗效,比较治疗前后两组患者血糖指标空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbAlc)、胰岛素(FINS)、血糖标准差(SDBG)、平均血糖波动幅度(MAGE)、日内血糖波动次数(NGE)及日间血糖平均绝对差(MODD)水平,及血清肿瘤坏死因子相关蛋白6(CTRP6)、1-磷酸鞘氨醇(SIP)、白细胞介素-18(IL-18)、C1补体肿瘤坏死因子相关蛋白12(CTRP12)和血清脂蛋白-α(LP)水平。结果治疗后,在总有效率上治疗组显著高于对照组(98.51%vs 83.58%,P<0.05)。治疗后,两组FPG、2 h PG、HbAlc、FINS水平均显著降低(P<0.05),且治疗组最显著(P<0.05)。治疗后,两组血清CTRP6、SIP、IL-18、LP水平均显著降低,而CTRP12水平显著升高(P<0.05),且以治疗组改善最明显(P<0.05)。治疗后,两组SDBG、MAGE、NGE和MODD均显著下降(P<0.05),且以治疗组降低最明显(P<0.05)。结论天芪降糖胶囊联合达格列净片治疗2型糖尿病可显著控制患者血糖,具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Tianqi Jiangtang Capsules combined with dagliejing in treatment of type 2 diabetes mellitus. Methods Patients(134 cases) with type 2 diabetes mellitus in the Second Hospital of Tianjin Medical University from August 2019 to September 2020 were randomly divided into control and treatment groups by random number table, and each group had 67 cases. Patients in the control group were po administered with Dapagliflozin Tablets, 10 mg/time, once daily. Patients in the treatment group were po administered with Tianqi Jiangtang Capsules on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the blood glucose indexes of FPG, 2 h PG, HbAlc, FINS, SDBG, MAGE, NGE, and MODD, and the levels of serum CTRP6, SIP, IL-18, LP, and CTRP12 in two groups before and after treatment were compared. Results After treatment, the effective rate of the treatment group was significantly higher than that of the control group(98.51% vs 83.58%, P < 0.05). After treatment, the levels of FPG, 2 h PG, HbAlc, and FINS in two groups were significantly decreased(P < 0.05), especially in the treatment group(P < 0.05). After treatment, the serum levels of CTRP6, SIP, IL-18, and LP in the two groups were significantly decreased, while the level of CTRP12 was significantly increased(P < 0.05), especially in the treatment group(P < 0.05). After treatment, SDBG, MAGE, NGE, and MODD in two groups were significantly decreased(P < 0.05), especially in the treatment group(P < 0.05). Conclusion Tianqi Jiangtang Capsules combined with dapagliflozin in treatment of type 2 diabetes mellitus can significantly control blood gluco se, which has a certain clinical application value.