苦参碱防治肾病的药理作用及其机制的研究进展

Progress on pharmacological effect and mechanism of matrine to preventing and treating nephropathy

苦参碱具有抗内毒素性肾损伤、抗化疗药肾损伤、抗免疫性肾损伤、抗尿酸性肾病、抗输尿管梗阻大鼠肾间质纤维化和抗糖尿病肾病的作用。苦参碱肾脏保护作用的机制可能是下调脂多糖识别受体的表达、抑制JAK/STAT通路、抑制PI3K/AKT/mTOR通路和抑制ERK1/2通路,从而阻断TGF-β1/Smad和NF-κB炎性信号通路,减轻肾脏炎症反应和细胞外基质沉积,产生延缓肾脏纤维化的作用。

Matrine has the effects of antagonisms to endotoxic renal injury, chemotherapeutic renal injury, immunity renal injury, uric acid nephropathy, renal interstitial fibrosis after ureteral obstruction in rat, and diabetic renopathy. The mechanisms of renal protection of matrine may down-regulate the expression of pattern recognition receptors for LPS, to inhibit the pathways of JAK/STAT, PI3K/AKT/mTOR, and ERK1/2, thus blocking the inflammatory signaling pathways of TGF-β1/Smad and NF-κB, and alleviating renal tissue inflammation and extracellular matrix deposit, and delaying fibrosis of kidney.