噬菌体抗感染及临床应用进展

Anti-infection effect of phage and its clinical application

近年来,细菌耐药性问题愈发严重,给全球公共卫生事业与医疗保健带来了困扰,研发新型抗菌药物需要投入更多的时间与资金。噬菌体作为一类能够特异性感染细菌、真菌、放线菌等微生物的病毒,可依赖宿主菌大量复制,种类丰富,且研发成本低,在抗感染治疗方面的价值十分可观,是具有巨大潜力的新一代生物抗菌剂。现通过对噬菌体杀菌机制、噬菌体抗感染方面研究进展以及临床应用进行综述,以期为噬菌体抗感染治疗及临床应用提供参考。

In recent years,the problem of bacterial resistance has become more and more serious,which has brought troubles to global public health and medical care.The time and money required to develop new antibiotics is even greater than before.Bacteriophage is a kind of virus that can specifically infect bacteria,fungi,actinomycetes and other microorganisms.Relying on host bacteria to replicate in large numbers,rich species,low research and development cost,the value of anti-infection therapy is very considerable.It is a new generation of biological antimicrobial agents with great potential.This paper briefly describes the sterilization mechanism,progress of research on anti-infection aspect and clinical application of phage,in order to provide reference for phage anti-infection treatment and clinical application.