T淋巴细胞亚群在非酒精性脂肪性肝病恶性转化中的作用机制

Mechanism of T lymphocyte subsets in the malignant transformation of non-alcoholic fatty liver disease

非酒精性脂肪性肝病正成为全球肝病相关发病率和病死率的主要原因,其病理学机制复杂,尚未完全清楚,免疫调节无疑是其发病过程中的重要环节,尤其T淋巴细胞亚群变化。现介绍T淋巴细胞参与脂肪变性、炎症、纤维化、恶性转化及免疫治疗的研究进展。

Nonalcoholic fatty liver disease is becoming the main cause of global liver disease-related morbidity and mortality.Notably,its pathological mechanism is complicated and not yet fully understood.Therefore,immune regulation is undoubtedly an important link in its pathogenesis,especially the change of T lymphocyte subsets.This article introduces the research progress of T lymphocytes involved in steatosis,inflammation,fibrosis,malignant transformation and immunotherapy.