摘要
目的探讨在脑电双频指数(BIS)监测下全麻妇科患者丙泊酚用量与血红蛋白之间的相关性。方法选取择期妇科腹腔镜手术患者48例,年龄35~55岁,ASAⅠ或Ⅱ级,体质量指数18~24 kg·m^(-2),采用脑电双频指数监测下丙泊酚全身麻醉。根据术前血红蛋白含量将入选患者分成正常组、轻度贫血组和中度贫血组,比较3组患者的一般资料、手术麻醉时间和丙泊酚使用量。结果 3组患者的一般资料、手术麻醉时间和血浆白蛋白等经比较,组间差异均无统计学意义。中度贫血组患者的丙泊酚使用量低于轻度贫血组或正常组(P <0.05),且血红蛋白与丙泊酚用量之间呈弱相关(r=0.293,P=0.046)。结论在BIS监测下,中度贫血的妇科患者在实施腹腔镜手术时需降低丙泊酚用量。
AIM To discuss the correlation between propofol dosage and hemoglobin in gynecological patients under general anesthesia by bispectral index(BIS)monitoring.METHODS A total of 48 patients,from 35 to 55 years old,ASAⅠorⅡ,BMI 18-24 kg·m^(-2),undergoing elective gynecological endoscopic surgery during genneral anesthesia were enrolled in this prospective study.Patients were divided into 3 groups based on preoperative hemoglobin level:normal hemoglobin group,mild anemia group and moderate anemia group,respectively.All patients used an unified anesthesia program,the general information and anesthesia time and propofol dosage of 3 groups were compared.RESULTS There were no significant differences in general information,anesthesia time,plasma albumin and so on among 3 groups.The dosage of propofol in moderate anemia group was lower than that in mild anemia group or normal hemoglobin group(P<0.05),and there was a weak correlation between hemoglobin and propofol dosage(r=0.293,P=0.046).CONCLUSION Under BIS monitoring,gynecological patients with moderate anemia need to reduce the dosage of propofol during laparoscopic surgery.
作者
潘媛媛
王瑜斐
庄秀秀
黄陆平
金深辉
王均炉
PAN Yuanyuan;WANG Yufei;ZHUANG Xiuxiu;HUANG Luping;JIN Shenhui;WANG Junlu(Department of Anesthesiology,The Frist Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China)
出处
《中国临床药学杂志》
CAS
2021年第3期169-173,共5页
Chinese Journal of Clinical Pharmacy
基金
国家自然基金(编号81573742)
温州市科技局课题(编号Y20180568)。