Landscapes of SARS-CoV-2-reactive CD8^(+)T cells:heterogeneity of host immune responses against SARS-CoV-2

In a recent study published in Science Immunology,^Kusnadi et al.performed single-cell RNA sequencing(scRNA-seq)of SARS-CoV-2-reactive CD8^(+)T cells and reported heterogeneity.SARS-CoV-2 infection causes COVID-19,which is an ongoing pandemic disease threatening public health.The virology of SARS-CoV-2 and immune responses against the virus have been urgently investigated to develop effective measures against COVID-19.During viral infection,CD84 T cells contribute to elimination of the virus by exerting cytotoxicity against virus-infected cells and producing effector cytokines,whereas neutralizing antibodies interfere with viral entry of host cells.