摘要
Dear Editor,The outbreak of the SARS-CoV-2 epidemic once again demonstrates that RNA viruses,through mutations,genetic recombination and cross-species transmission,can pose a serious threat to the health of people worldwide.Even after the severe acute respiratory syndrome(SARS)and middle east respiratory syndrome(MERS)outbreaks,the world still initially lacked effective means to control the current coronavirus disease 2019(COVID-19)outbreak.We must work together to develop effective drugs to treat existing and future potential coronavirus infections to reduce their impact on the global health system and human life.Due to time constraints,the'conventional drug in new use#method has become the main method of treating SARS-CoV-2 infections.However,long-term drug development goals should include treatments that can produce broad-spectrum effects on different coronaviruses,and provide the means to alleviate disease symptoms and prevent death.
基金
This work was supported by the National Key Research and Development Program(No.2016YFC1303502)
National Major Scientific and Technological Special Project for"Significant New Drugs Development(2018ZX09733001)
1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University,the Special grant from China Postdoctoral Science Foundation(No.2020TQ0217)
the Post-Doctor Research Project,West China Hospital,Sichuan University(No.2020HXBH173)
Post-Doctor Research Project,Sichuan University(No.2021SCU12028).