Neuroform支架治疗症状性颅内动脉粥样硬化性狭窄的临床研究

Clinical Study of Neuroform Stent in the Treatment of Symptomatic Intracranial Atherosclerotic Stenosis

目的:研究Neuroform支架治疗症状性颅内动脉粥样硬化性狭窄的安全性及有效性。方法:回顾性分析2018年1月-2020年3月本院神经内科收治的症状性颅内动脉粥样硬化性狭窄患者65例(存在66个靶病变血管),术前经脑血管造影(DSA)明确诊断,并接受Neuroform支架治疗。术后1、3个月进行临床随访,术后6个月进行临床及影像学随访。对颅内动脉支架置入情况进行观察,并比较手术前后血管狭窄率、评价临床疗效及并发症发生情况。结果:65例患者均成功置入Neuroform支架,手术成功率为100%;DSA显示术后血管狭窄率比术前更低(P<0.05)。术后1、3、6个月NIHSS评分、mRS评分均低于术前(P<0.05)。住院期间发生脑桥梗死患者1例(1.54%),症状性脑出血1例(1.54%)。随访期间再发脑卒中1例,支架内再狭窄1例,总发生率为3.08%。结论:Neuroform支架治疗症状性颅内动脉粥样硬化性狭窄疗效确切,安全性较高,预后良好。

Objective:To study the safety and efficacy of Neuroform stent in the treatment of symptomatic intracranial atherosclerotic stenosis.Method:A total of 65 patients with symptomatic intracranial atherosclerotic stenosis (66 target vessels) admitted to the Department of Neurology in our hospital from January 2018 to March 2020 were retrospectively analyzed.The patients were diagnosed by digital substraction angiography (DSA) before operation and treated with Neuroform stent.Clinical follow-up was conducted at 1 month and 3 months after operation,and clinical and imaging follow-up was conducted 6 months after operation.The angiographic stenosis rate before and after operation,clinical efficacy and complications were compared.Result:Neuroform stents were successfully implanted in all 65 patients,and the success rate of operation was 100%.DSA showed that the rate of vascular stenosis after operation was lower than that before operation (P<0.05).The NIHSS score and mRS score at 1,3 and 6 months after operation were lower than those before operation (P<0.05).During the period of hospitalization,there was 1 case with pontine infarction (1.54%) and 1 case with symptomatic intracerebral hemorrhage (1.54%).During the follow-up period,there was 1 case with recurrent stroke and 1 case with stent restenosis,the total incidence was 3.08%.Conclusion:Neuroform stent is effective,safe and has a good prognosis in the treatment of symptomatic intracranial atherosclerotic stenosis.